Earl Edward Wegner was born in Cheney, Washington on June 21, 1885. He received his Doctor of Veterinary Medicine from WSU in 1908 and Bachelor of Science in 1915. He served as Assistant Professor of Veterinary Anatomy and Surgery from 1909-1913. From 1914-1916 he was Associate Professor of Anatomy and Surgery and from 1917 he was a full Professor. In 1921 he was made Dean of the College of Veterinary Science and continued in that office until 1947. He was also mayor of Pullman from 1926-1930. He died on November 23, 1965.

Classes in veterinary medicine have been taught at Washington State University since the institution's beginning. In 1899 the veterinary program was organized into the School of Veterinary Science, and the granting of professional degrees for a three-year program in veterinary medicine was introduced. The first graduating class, consisting of two individuals, received their degrees in 1902. In 1906 the degree program expanded from three to four years of study.

Beginning in 1908 senior veterinary students were taught at a clinic in Spokane, where they could receive more practical experience, while all other students were taught in Pullman. This arrangement continued until 1923 when all teaching facilities and staff were brought to Pullman. In 1917, as a result of President E. O. Holland's reorganization of the institution, the School of Veterinary Science became the College of Veterinary Science. The name was altered to the College of Veterinary Medicine in 1925. In the 1930's the degree program was expanded to five years of study. Reorganization in 1944 made the College of Veterinary Medicine a subdivision of the Institute of Agricultural Sciences until, due to pressure from local and national veterinary organizations, the College regained its autonomy in 1950.

In 1979, in partnership with the University of Idaho, Montana State University and Utah State University, the Washington-Oregon-Idaho Regional Program in Veterinary Medical Education is formed, allowing students from various western states access to a veterinary medical education, without paying out-of-state tuition.

The School completed a new 110,000 square foot Veterinary Teaching Hospital in 1996. And in 2012 the Paul G. Allen School for Global Animal Health was created, committed to developing innovative strategies for the treatment and control of diseases that directly affect public health, economic development, and human opportunity.

A more extensive history of the College of Veterinary Medicine can be found in: Harriman, Peter, Pettit, Ghery D, Washington State University. College of Veterinary Medicine. "First Century: a Centennial History." Pullman: Washington State University; 1998.