Earl Warren Davie was born in 1927 in Tacoma, Washington. He attended the University of Washington where he took a course in biochemistry taught by Donald Hanahan. Davie got his first taste of laboratory research when Hanahan invited him to work in his laboratory on a senior project. He enjoyed it immensely, and when he received his B.S. in 1950 Davie decided to remain at the University of Washington to do graduate studies. He chose to work with Hans Neurath to learn about protein structure and function. For his thesis research, Neurath suggested that Davie compare trypsinogen and trypsin to gain some insight into the mechanism of zymogen activation. This resulted in Davie and Neurath's isolation of an acidic peptide that was generated by limited proteolysis during the activation of trypsinogen. The appearance of this peptide correlated exactly with the formation of the enzymatic activity of trypsin. Little did Davie and Neurath realize that “limited proteolysis” would be a common mechanism seen over and over again in biological systems, including the blood coagulation to which Davie would eventually devote much of his research.
Davie received his PhD in 1954. Neurath recommended he do postdoctoral work with Fritz Lipmann. After 2 years in Lipmann's laboratory, Davie accepted a faculty position in the Department of Biochemistry at Western Reserve University in Cleveland, Ohio. Davie's initial studies in Cleveland dealt with the isolation and identification of aminoacyl adenylates that had been proposed as intermediates in the carboxyl activation of amino acids. In 1957, Davie met Oscar Ratnoff, a distinguished Professor of Medicine and expert in blood coagulation at Western Reserve University. The meeting turned Davie's career in an entirely new direction as he began to collaborate with Ratnoff. Davie's first project with Ratnoff involved the isolation of a plasma protein that was missing from a patient named John Hageman whose blood didn't clot when added to a glass test tube. Using column chromatography, Davie was able to isolate the Hageman factor, which is now known as factor XII. He and Ratnoff continued the purification of Hageman factor as well as PTA (plasma thromboplastin antecedent or factor XI) and Christmas factor (factor IX).
In 1962 Davie received a letter from Hans Neurath inviting him to join the faculty in the Department of Biochemistry at the University of Washington in Seattle.
Source: https://www.jbc.org/article/S0021-9258(20)72075-2/fulltext
see also: https://sites.uw.edu/biochemistry/autumn-2020-newsletter/remembering-earl-davie/
Arranged in 5 series.
Correspondence, memos, letters of recommendation, mailings, grant applications, fellowship applications, reports, lab notebooks, syllabi, class readings, lecture notes, blank exams, manuscripts, drafts, articles, notes, minutes, travel materials, photographs, computer disks, and other materials from the career of a professor and later department head of Biochemistry at the University of Washington. Includes applications and related materials for which Davie served as a sponsor.
Digital media is closed until evaluated.
Access to portions of the collection is restricted. Contact University of Washington Libraries Special Collections for details.
Digital media is closed until evaluated.
Creator's copyrights not transferred to the University of Washington Libraries.
Materials that provide a biographic overview of Davie's work, personal materials on memorials and celebrations, and biographic material on notable people Davie worked with.
Website profiles from UW Biochemistry, Wikipedia, American Society of Hematology, the Vallee Foundation, Centre for Blood Research, and Cardiovascular News
Summary of awards, CV, and award nominations
Includes Neurath's bibliography
Correspondence regarding memorial planning and fundraising, photograph of Neurath, obituary, and letter regarding the Hans and Susi Neurath Assistant Professorship
Bibliographic memoirs and drafts
Davie and Fischer wrote the bibliographic memoir for Neurath
Birthday celebration program on protein dephosphorylation, highlights of Fischer's career, and introductions for Nick Tonks, Bill Whelan, and Phil Cohen
Correspondence and bibliographic memoir proofs written by Davie
Personal and professional correspondence, including letters regarding university matters, research work, job inquiries, and letters of recommendation.
Discussion of Davie's research and lab, funding, requests for article reprints, and potential research positions
Requests for seminars from visiting professors, professional travel documents, current activity reports, staff meeting information, job positions, and committee correspondence
Memos, articles, and miscellaneous notes kept with correspondence
Correspondence, letters of recommendation, and other materials relating to people who worked within Davie's laboratory
American Society for Biochemistry and Molecular Biology, American Society of Hematology, American Heart Association, National Board of Medical Examiners, Washington State Heart Association, and World Federation of Hemophilia
Hyland Laboratories, Kabi, and Puget Sound Blood Center
Correspondence related to patents, Primate Center, radiation and laboratory safety, and recombinant DNA
Correspondence, grant materials, letters of recommendation for Davie's colleagues, and article reprints co-authored by Davie
Correspondence, grant materials, letters of recommendation for Davie's colleagues, and article reprints co-authored by Davie
Correspondence, grant materials, letters of recommendation for Davie's colleagues, and article reprints co-authored by Davie
Correspondence, grant materials, letters of recommendation for Davie's colleagues, and article reprints co-authored by Davie
Professional correspondence
Correspondence regarding position vacancies
Correspondence regarding protentional position openings
Restricted
Miscellaneous confidential correspondence
Restricted
Materials relating to Davie's research and publications, including grant materials, research notes, manuscripts, and publications.
Grant materials for studies Davie was the Principal Investigator for, trainee support documents, and reprints of articles co-authored by Davie. Grants are on the mechanisms and proteins for blood coagulation.
Grant materials for studies Davie was the Principal Investigator for, trainee support documents, and reprints of articles co-authored by Davie. Grants are on the mechanisms and proteins for blood coagulation.
Grant materials for a study Davie was the Principal Investigator for
Grant materials for a study Davie was the Principal Investigator for
Grant materials for a study Davie was the Principal Investigator for
Grant materials for a study Davie was the Principal Investigator for
Grant materials for a study Davie was an Associate Investigator for
Richard Counts was the Principal Investigator for this study.
Grant materials for a study Davie was a Collaborating Investigator for
Kathleen Palmer Pratt was the Principal Investigator for this study.
Grant materials and list of trainees that were paired into Davie's lab. Training was on topics such as urology, hematology, and cardiology.
Equipment grant materials for enzymatic studies
Statement of consultation by Davie for Takayama's study "The Role of Serine Proteases in Prostatic Diseases"
Grant materials and statement of consultation by Miao's study on nonviral gene therapy for hemophilia treatment
Correspondence regarding biochemical samples Davie sent to other researchers
Photographs, negatives, and slides of miscellaneous lab tests
Lists of lab members and biographical information
Products parts lists, instructions, and small objects included with these materials
Radiation safety documents for Davie's lab
Eli Lilly and Company and Zymogenetics appeal brief and correspondence
Notebooks by Davie, Antero So, Kathleen Downey, and Henry Kingdon
Research drawings, graphs, and photographs from the conference
Research drawings, graphs, notes, and photographs of the Gordon Conference
Revised research activities and proposal from the King County Central Blood Bank
Manuscript drafts, notes, and research data
Memos and seminar summaries
Correspondence, notes, photographs, and manuscript by Meyer, Germershausen, and Suskind
Correspondence
Notes on the following topics: membrane filtration, reagents, antibodies to AHF, coagulation kinetics, kinetics, Factor V, Factor VIII, clinical concentrates of Factor IX, Complement, polysaccharides, proteins, structure of macromolecules, mechanism of Vitamin K action, phasminogeny streptokinase, synthetic polynucleotides, streptomycin, and miscellaneous seminars
Manuscript topics include: molecular cloning, the assembly of fibrinogen, 5'-flanking region, human DNA polymerase delta, Factor XI deficiency in Ashkenazi Jews, proteins of blood coagulation, blood coagulation cascade, fibrinogens, and Factor VII
Manuscript topics include: endopeptidase, Factor XI, Factor VIII, Protein C gene, Factor X, DNA polymerases, plasma kallikrein, blood coagulation cascade, metallothionein, human actin-binding protein, gamma-chain dysfibrinogenemias, fibrinogens, proline-rich Gla proteins, primary fibrin polymerization pocket, and a precursor of prostate specific antigen
Diagram topics include: Factor V, protein methyltransferases, Factor VII, Factor X, Factor IX, Factor XI, Factor XII, Factor XIII, Protein C, plasminogens, von Willebrand Factor, fibrinogens, plasma prekallikrein, human platelet glycoprotein, Protein S, blood coagulation cascade, and prothrombin
Full run of Davie's publications
Notes that were originally kept with the physical digital media in Box 12
Likely backup files and documents from Davie and his collaborators
Materials relating to Davie's academic studies, teaching, and work at the University of Washington.
Includes pamphlets, lecture speeches, workshop materials, registration data, course information, and notes
Notes for classes and seminars Davie attended
Correspondence, biochemistry exam negatives, regulation materials for the biochemistry department, and photographs
Syllabi, readings, lecture notes, and blank exams for classes taught by Davie
Syllabi, readings, lecture notes, and blank exams for classes taught by Davie
Correspondence, itineraries, lecture information and drafts, travel documents, programs, notes, and photographs of the various lectures, conferences, seminars, and symposiums that Davie participated in and spoke at
Notebooks containing Davie's notes from seminars and talks he attended
Correspondence, itineraries, lecture information and drafts, travel documents, programs, notes, and photographs of the various lectures, conferences, seminars, and symposiums that Davie participated in and spoke at
Correspondence, itineraries, lecture information, printed slides, and notes
Draft copy and related correspondence by Clement A. Finch
Meeting minutes, enrollment data, surveys, course outlines, Davie's CV, and general questions for the independent study program
Correspondence, memos, teaching assignments, meeting materials, and statistics on the Department of Biochemistry
Department plan for the Department of Biochemistry for 1974-1981 and related correspondence
Memos and correspondence
Memos, correspondence, and reports for the Department of Biochemistry
Floor plan for Kane Hall
Commencement address for the chemistry and biochemistry departments given by Davie, drafts, and correspondence
Journal with listed events and articles about the school
Photographs of professors, members of the Department of Biochemistry, and personal photographs Davie had framed
Correspondence, receipts, and itineraries for the annual picnic for Davie's Lab
Photographs of the Department of Biochemistry, memos, booklet on faculty research, and program booklet for the Interdisciplinary Molecular and Cellular Biology Program
Newsletters, correspondence, memos, and descriptions of the training program
Results of the 1986 superfinal, blank exams, correspondence, and drafts
Meeting minutes, correspondence, and applicant information of the Chairman of the Department of Microbiology and Immunology
Dr. Eugene W. Nester filled the role of Chairman.
Restricted
Correspondence, nomination for award, and drafts
Grant and fellowship applications
Restricted
Correspondence and article on Connie Kravas being selected as Vice President for Development and Alumni Relations
Correspondence, itineraries, program booklets, and lecture information
Correspondence, staff and board information, Pacific Northwest Ballet tickets, and drafts
Correspondence, itinerary, and invitation lists
Program booklets, correspondence, lecture information, itineraries, biographical sketches, invitations, invitation lists, notes, and drafts
Correspondence, Neurath's CV, program booklets, and articles
Correspondence, newsletters, memos, meeting minutes, drafts, notes, and other miscellaneous documents
Miscellaneous newspaper comics
Speaker request forms and biochemistry journal letterhead
Instructions on electrofocusing, object codes, telephone use, and mailing
Materials from conferences Davie attended, committees he was a part of, and chapters he contributed to other people's work.
Committee meeting materials, itineraries, and correspondence
Visitor booklet, correspondence, progress reports, articles, and summaries
Travel expense documents, correspondence, draft reports, itineraries, meeting minutes, statements of employment and financial interests, newsletters, and memos
Correspondence, itineraries, meeting materials, and memos
Correspondence, application forms, and documents inviting the ISTH to host their 14th Congress in 1993 in Seattle
ISTH decided to host their 14th Congress in New York City instead of Seattle.
Correspondence, travel expenses, meeting summaries, itineraries, and notes
Itineraries, notes, correspondence, and conference information
Correspondence, program booklets, and travel expenses
Correspondence
Memos, questionnaire results, correspondence, teaching assistant assignments, and committee materials
Correspondence, itineraries, and notes
Travel expenses, correspondence, itineraries, photograph of the 20th Linderstomlang Conference, maps, article reprints, presentation materials, Euro Courses information, research drafts, program booklets, annual report of Novo Nordisk, and UW Biochemistry Advisory Board materials
Notes, correspondence, and itineraries
Correspondence, notes, itineraries, and article reprints with marginalia
Correspondence, travel documents, and notes
Correspondence, itineraries, and travel expenses
Correspondence, notes, itineraries, and article with marginalia
Correspondence, memos, travel documents, and conference materials
Correspondence, memos, meeting minutes, and meeting minutes
Newsletter and correspondence
Travel documents, memos, and committee materials
Travel documents, notes, correspondence, and itineraries
Correspondence
Correspondence, travel documents, and notes
Travel documents, constitution and bylaws booklet, correspondence, memos, committee materials, and notes
Memos and correspondence
Memos, travel documents, correspondence, and study section materials
Newsletters, memos, communication, and council materials
Newsletters, correspondence, and committee materials
Correspondence and faculty position summary draft
Correspondence and handbook chapter materials
Correspondence, figures, and textbook chapter materials
Correspondence and textbook chapter materials
Correspondence
Correspondence and textbook chapter materials
Guidelines and correspondence
Correspondence
Correspondence and textbook chapter materials
Correspondence and textbook chapter materials
Memos, correspondence, and textbook chapter materials
Correspondence and textbook chapter materials
Correspondence on subject review