UUM_Accn1437 Inventory of the Jarvis Edwin Seegmiller papers, 1942-1992 Seegmiller (Jarvis Edwin) papers Finding aid created by Debra Penman Manuscripts Division, J. Willard Marriott Library, University of Utah
295 South 1500 East Salt Lake City, Utah 84112-0860 801-581-8864 http://www.lib.utah.edu/Collections/manuscripts.php
© 1997 (last modified: 2019) Finding aid encoded by Avichal Mishra and Lisa DeMille 2007 Finding aid encoded in English in Latin script. Finding aid based on DACS (Describing Archives: A Content Standard, 2nd Edition) University of Utah Libraries, Special Collections Manuscripts Division
Special Collections 295 South 1500 East Salt Lake City, Utah 84112-0860 801-581-8864 http://www.lib.utah.edu/Collections/manuscripts.php
ACCN 1437 Jarvis Edwin Seegmiller papers 1942-1992 Seegmiller, J. E. 80.75 linear feet The Jarvis Edwin Seegmiller papers (1942-1992) contain personal and professional correspondence, biographical material, class notes, business office files, catalogues, conference and seminar files, desk material, illustration files, patient related files, proposals and reports, specimen records and laboratory office files, charts, graphs, medical illustrations, transparencies, awards, equipment instruction, lab notebooks, architectural drawings, speeches, manuscript drafts, papers, and general research notes. J. E. Seegmiller (born 1920) is a prominent scientist concerned with the illnesses affecting the elderly. Collection materials are in English. Biographical Sketch

Jarvis Edwin (Jay) Seegmiller was born to Edwin Dee and Eleanor Woodbury Jarvis Seegmiller on June 22, 1920 in St. George, Utah. He is the grandson of early Mormon settlers, and Seegmiller Mountain (the highest point on the southern horizon of St. George) was named after his grandfather's ranch. He is the youngest of nine children, and the only son.

He was first introduced to the idea of becoming a scientist in 1936 by Dr. Henry Eyring, who, at the time, was a professor of chemistry at Princeton University. Dr. Eyring's family grew up in St. George, and they were close friends with the Seegmillers. Dr. Seegmiller graduated from Dixie Junior College in St. George in 1940 as the valedictorian. The next year, he transferred to the University of Utah where he graduated in 1942 with an A. B. in Chemistry. He was accepted into the graduate schools of chemistry at both Princeton and Pennsylvania State University, but the onset of World War II prevented his attendance at either one.

Fortunately, a war research project for the National Defense Research Committee took him to the National Institutes of Health (NIH) where he met physicians working on human diseases that had a basis in chemical abnormalities of the body. Finding this more fascinating than anything he had encountered in the chemistry laboratories, he applied to medical school and was accepted at the University of Chicago in 1945, after his discharge from the army. He then graduated three years later with honors. After interning at Johns Hopkins Hospital, he obtained additional research training in biochemistry at the National Institute of Arthritis and Metabolic Diseases of the NIH in Bethesda, Maryland.

While living in Washington, D.C., his roommate suggested that he meet a friend of his from New York, Roberta Mae Eads. She was working on Wall Street as a tax accountant, and Jay was impressed with her from the moment he met her. On their third date, he proposed to her, and she accepted. They were married in the Salt Lake LDS Temple on November 1, 1950. They had been married for almost 42 years when Roberta died of metastatic endometrial cancer and chronic lymphocytic leukemia in August 1992.

Together, Jay and Roberta had four children and seven grandchildren. Their children are Susan Dale, Robert Edwin, Lisa Kristine, and Richard Lewis; and they are married to Craig Lloyd Maudlin, Ruth Jacob, John Robert Taylor, and Marianne Shumway respectively.

In 1952, Dr. Seegmiller became a Research Associate at Harvard Medical School. The following year, he became a Visiting Scientist Investigator at the Public Health Research Institute of the City of New York. In 1954, he returned to the National Institute of Arthritis and Metabolic Diseases as a Clinical Investigator. Then, after spending a year in London studying human genetics, he was appointed Chief to the Section on Human Biochemical Genetics in 1964.

In 1969, he joined the medical faculty of the newly created University of California in San Diego (UCSD) as Professor of Medicine, Director of the Division of Rheumatology, and Director of the Human Biochemical Genetics Program. In late 1983, he was appointed Founding Director of UCSD's newly established Institute for Research on Aging. In 1990, he became Professor Emeritus, but continued as Associate Director at the Institute for Research on Aging.

Dr. Seegmiller's research interests have centered on the genetic and biochemical mechanisms responsible for production of human hereditary disease states, including several forms of arthritis and a number of neurological diseases. His work has been recognized internationally. In fact, between 1968 and 1990, he received twenty distinguished awards and honors including the Geigy Award, the Heberden Society Medal, and the Philip Hench Award. He was also given two Distinguished Service Awards, one from the University of Chicago in 1980, and the other from the Alumni Association of the University of California, San Diego in 1990.

He was a member of thirteen different scientific associations, including the National Academy of Sciences. During 1970, he was the Harvey Society Lecturer. He is the former chief of the Section on Human Biochemical Genetics at the National Institute of Arthritis and Metabolic Diseases; and, between 1948 and 1991 he wrote, edited, or co-wrote 341 publications (more information on these publications is provided in his curriculum vitae).

The Jarvis Edwin Seegmiller papers (1942-1992) have been divided into four sections. Every attempt was made to preserve the original order of the Collection, but it had to be arranged in a format that would make the papers easy to research. Although there is some duplication and crossover of the material between sections, it is not substantial.

Section One contains information on Dr. Seegmiller's personal life and professional training. Box 1 contains all of his correspondence. Box 2 contains information on his personal life and family. Boxes 3-7 contain notes taken during his years at the University of Chicago Medical School. There are fifteen different subjects upon which he took notes, and those subjects are arranged in alphabetical order.

Section Two contains information from Dr. Seegmiller's files. This section has been divided into nine groups of information: business office files, catalogues, conference and seminar files, desk material, illustration files, patient related files, proposals and reports, specimen records and laboratory office files, and unidentified notes. Whenever possible, the files were kept in the order in which Seegmiller had arranged them.

Several folder titles in the business office files (boxes 8-21) start with the acronym UCSD, which stands for the University of California, San Diego. Every grant or research proposal funded by that university was given a UCSD number for clarification on paperwork. Boxes 20 and 21 contain an extensive file, "The General View of Subjects on Aging Related Research Supported by the National Institutes of Health." This file is divided into several subsections identified by their folder titles, and represents topics sanctioned by the National Institutes of Health.

Boxes 28-30 contain materials taken out of his desk and off the walls of his office. A major portion of this group consists of old calendars, but only pages with information written on them were retained. The illustration files in boxes 31 and 32 contain charts, graphs, medical illustrations, photocopies of photographs and slides (the originals are in the Multimedia Section of the Manuscripts Division, P0622), transparencies, and tables. Some of the items in these files were used in Seegmiller's papers, books, and lectures.

The final group of this section (boxes 44-47) contains charts, graphs, and handwritten notes taken during research and/or experiments. However, for most of these files, there is no indication of who did the research, when it was done, what it was, or why it was being done. A more detailed explanation of specific research can be found in Section Four of this Collection.

In 1996, Seegmiller donated an additional group of office files (Boxes 133-164). Box 133 contains general office material such as notes, correspondence, awards, information on visiting professors, and equipment instructions. Boxes 134-138 contain more information on grants and research proposals. The largest portion of these grant files are related to the Human Biochemical Genetics Program (HBGP). These files are organized by each of the twelve years that this grant was awarded, and then followed by miscellaneous material related to the program. Boxes 139-164 contains correspondence, pamphlets, programs, abstracts, related articles, and lecture notes for more of the conferences, symposiums, and annual group meetings upon which Seegmiller attended or received information. At many of these gatherings, he gave a lecture on gout, metabolism, or geriatric health care.

Section Three contains material used in Seegmiller's publications. Boxes 48 and 49 contain material used in his various appearances as a guest lecturer, or by his colleagues for one of their own lectures. Boxes 50 and 51 contain research material and some of Seegmiller's resulting publications. For some of the writings, Dr. Seegmiller was a co-author whose name is not listed first. Boxes 52-61 contain writings by some of Seegmiller's associates, and he used many of them as research for his own articles. Boxes 62-65 hold Seegmiller's bibliographic reference system. Whenever he did research, he kept a bibliography of every source he used. Then, he put those sources on these cards so that, in the future, he could gain access to them easily.

Section Four materials document the identifiable research done by Dr. Seegmiller or one of his assistants. The notebooks in boxes 69-109 contain detailed notes of Dr. Seegmiller's procedures and experiments. These notebooks are arranged in chronological order. Boxes 110-131 contain the laboratory notes of his assistants and/or students. These notebooks are arranged in alphabetical order by the last name of the author. If there is more than one book written by the same person, then those books are arranged in chronological order.

Box 132 contains architectural drawings of the rooms in which Dr. Seegmiller conducted his experiments (which were remodeled for his own use) at the National Institutes of Health. The ideas and notes for these renovations can be found in Section One, at the beginning of box 8.

Organized in five series: I. Personal Papers; II. Office Files; III. Research Materials; IV. Experimental Research Notebooks; V. 1996 Addendum.

Access to Boxes 34 and 35 restricted except by permission of the Curator of Manuscripts.

Twenty-four hour advanced notice encouraged. Materials must be used on-site. Access to parts of this collection may be restricted under provisions of state or federal law.

The library does not claim to control copyright for all materials in the collection. An individual depicted in a reproduction has privacy rights as outlined in Title 45 CFR, part 46 (Protection of Human Subjects). For further information, please review the J. Willard Marriott Library’s Use Agreement and Reproduction Request forms.

Collection Name, Collection Number, Box Number, Folder Number. Special Collections, J. Willard Marriott Library, The University of Utah.

Gift of Jarvis Edwin Seegmiller in 1994 and 1996.

Processed by Debra Penman in 1997.

Photographs and audio-visual materials were placed in the Multimedia Division of Special Collections (P0622 and A0362).

 Seegmiller, J. E --Archives Medical research personnel--United States Genetic disorders Joints--Diseases--Genetic aspects Arthritis--Genetic aspects Nervous system--Diseases--Genetic aspects Medicine and Health Notes Correspondence Reports Notebooks Reprints Architectural drawings Photographs I. Personal papers

The material in boxes 1 through 7 contain information on Jarvis Edwin Seegmiller's professional training and personal activities. Box 1 contains his correspondence. In Seegmiller's professional letters, it was his practice to type only the body of the letter, and then superimpose the final draft of that letter onto a piece of letterhead from the University of California, San Diego. An example of this letterhead can be found in folder 1 of this box. Box 2 contains information on his personal life and family. Boxes 3 through 7 contain notes taken during his years in medical school, 1945-1948. There are fifteen different subjects upon which he took notes, and those subjects are arranged in alphabetical order.

 1 Correspondence 1958-1991 1 University of California, San Diego Letterhead 2-31 Correspondence June 1958-September 1991 2 Personal Life 1 Family Photographs 2 Selected School Records of His Children 3-7 Financial Records 1942-1946 8-10 Income Tax Information 1963 11 Curriculum Vitae 12 Conference Photographs 13 Alumni Association Bulletin, University of Chicago School of Medicine 14 Retirement Information 15 Incomplete Autobiography 16 Family Genealogy Sheets 17-20 Address Lists 3 Medical School Class Notes 1945-1948 1-17 Anatomy and Physiology 18-32 Biochemistry 4 Medical School Class Notes 1945-1948 1-20 Chemistry 21-23 Embryology 24 English Literature 25-32 Hospital Rotations 5 Medical School Class Notes 1945-1948 1 Internal Medicine--Arthritis 2-3 Internal Medicine--Cancer Research 4-5 Internal Medicine--Cardiology 6-8 Internal Medicine--Chest and Thorax 9-12 Internal Medicine--Dermatology 13-17 Internal Medicine--Dietetics 18-19 Internal Medicine--Ear, Nose, and Throat 20-21 Internal Medicine--Gastro Intestinal 22-24 Internal Medicine--Hematology 25-26 Internal Medicine--Hypertension 27-28 Internal Medicine--Metabolism 29 Internal Medicine--Neurology 30-33 Internal Medicine--Ophthalmology 34-35 Internal Medicine--Orthopedics 6 Medical School Class Notes 1945-1948 1-2 Mathematics 3-10 Obstetrics and Gynecology 11-12 Parasitology 13-28 Pathology 29-32 Pediatrics 7 Medical School Class Notes 1945-1948 1-2 Pharmacology 3-7 Psychiatry 8-29 Miscellaneous Subjects

These notes were grouped together at the back of a file drawer.

 II. Office Files

This section has been divided into nine groups of information: business office files, catalogues, conference and seminar files, desk material, illustration files, patient related files, proposals and reports, specimen records and laboratory office files, and unidentified notes. The material in these groups overlap to some extent and duplicate information is present. Several folder titles in the business office files start with the acronym UCSD, which stands for the University of California, San Diego. Every grant or research proposal funded by that university was given a UCSD number for clarification on paperwork. Boxes 20 and 21 contain an extensive file, "The General View of Subjects on Aging Related Research Supported by the National Institute of Health." This file is divided into several subsections identified by folder titles, and represents topics sanctioned by the National Institutes of Health. Whenever possible, all the files were kept in the order in which Seegmiller had them arranged in his filing cabinets.

 8 Business Office Files 1 Academic and Staff Parking Permit Application 2-6 Alterations and Renovations Information 7 "Announcement of the National Science Foundation Graduate Fellowships for the Academic Year 1988-89" 1988-89 8 Budget and Funding Information 9-10 Cancer Research Coordination Committee 11-13 Contract Guidelines 14-17 Current Research 1971-1972 18 Epilepsy Foundation Information 19 Facility Certifications of Environmental Conditions 20 lesch Nyhan Forms and Program 21-24 Meeting Minutes for Clinical Research Center Advisory Committee 1974 25 Practice Exercises 26 Regents' Undergraduate Instructions for Improvement on Grant Guidelines 27 Resume of Michael S. Fisher, Ph.D. 28-33 Therapy for Calcium Phosphate Crystal Deposition Disease 34-35 University of California, San Diego Registration Materials 1973-1974 36 AFSCME Newsletter Vol. 2, no. 7 37 Campus Staff Gazette 1974-1976 38 Project Wildlife: A Second Chance 1977 9 Business Office Files 1-10 Reprinted Publications Supported by the National Institute of Health Grant AG07996 11-13 The San Diego Union newspaper, Section A 20 June 1976 14-20 Tissue Culture Abstracts 1974-1976

Vol. 11, no. 6-Vol. 13, no. 4.

 21 Tissue Culture Abstracts 1976

Vol. 13, no. 6.

 22 Tissue Culture Abstracts 1978

Vol. 15, no. 3.

 23-28 Claude D. Pepper Older American Independence Center's Research 29 Sandoz Institute's International Study on the Problems of the Elderly 10 Business Office Files 1-24 Renewal of Studies of Joint Aging and Osteoarthritis February-December 1991 25-29 Aging Chondrocalcinosis, Osteoarthritis, and Osteoporosis 11 Business Office Files 1-27 Aging Research Program Information 28-30 Background Information on Grant Proposal for Aging Research Program 12 Business Office Files 1-4 Changes of Joint Tissue Metabolism with Aging Project 5-9 Oxidative Tissue Damage Project 1989 10-28 Oxidative Tissue Damage Project 1989-1990 13 Business Office Files 1-12 Oxidative Tissue Damage Project 1990 13-32 Oxidative Tissue Program Project October 1990 14 Business Office Files 1-5 Oxidative Site Visit January 1991 6-9 Oxidative Tissue Damage, Aging, and Degenerative Diseases 10 Pilot Program of Lesch-Nyhan Syndrome Research 11-14 Purine Metabolism in Aging and Osteoarthritic Cartilage 15-19 Regional Medical Program, Imperial Valley 1974 20-21 Senior International Fellowship Program 1975 22 Visiting Professorship in Nutrition Program 23 Chromatographic Methods Manual 1980 24 Hybridoma Techniques Manual 1980 25-31 Human Heredity Disease Manual 15 Business Office Files 1-4 Laboratory Procedures Manual 1987 5 Manual of Diets and Procedures 6 Membrane Filtration Manual 1975 7-8 NFG Genetic Counseling and Treatment Network Manual 9 Operation and Service Manual for the Model 111 Fluorometer 10-13 Oxford Methods Manual 1980 14-16 Principles and Practice of Medical Genetics Manual 1981 17 Rheumatology Study Manual 18 Rheumatology Slide Program 19 Rheumatology Teacher's Manual 20-22 Training Manual for Physicians/Scientists Working in the National Institute on Aging 23-24 Turner laboratory Instruments Manual 1967 & 1972 16 Business Office Files 1-5 University of California, San Diego (UCSD) # 5646--Genetic Control of Human Metabolism 1970-1973 6 UCSD # 5646--Extension Request to June 1977 June 1977 7-10 UCSD # 5888--Genetic Control of Human Metabolism 1973-1974 11-15 UCSD # 6492--Assessment and Control of Oxidant Induced Damage with Aging 16 UCSD # 6958--Genetic Control of Human Metabolism 1974-1975 17-19 UCSD # 7367--United Cerebral Palsy September 1974 20-22 UCSD # 7579--The Lesch/Nyhan Syndrome 23-29 UCSD # 7607--National Institute of Child Health and Human Development 30-31 UCSD # 8263--Adenosine Deaminase Deficiency 1975-1977 17 Business Office Files 1-5 UCSD # 8674--The lesch/Nyhan Syndrome 6-12 UCSD # 9151--United Cerebral Palsy Application August 1976 13-14 UCSD # 9253--Lupus Erythematosus February 1977-January 1978 15 UCSD # 886681--Aging Geriatric Health Education Response Research 16-34 UCSD # 91-5253--Studies of Joint Aging and Osteoarthritis 18 Business Office Files 1-8 Boss Grants 1980-1986 9-10 Claude D. Pepper Grant 11-15 Genetics Centers HBGP Grant 16-17 Grant Proposals 1968 18-35 Intracellular PPi in Chondrocytes Grant Proposal 1991 19 Business Office Files 1-2 Miscellaneous Grant Applications 3-15 Oxidative Tissue Damage, Aging, and Degenerative Disease Grant Proposal May 1989 16 VAH Training Grant Proposal 20 Business Office Files--General View of Subjects Supported by the National Institutes of Health 1 Overview of Subjects 2 Analyses 3-7 Cellular Science 8-9 Molecular Biology 10-13 Biochemical Biology 14-18 Physiology 19 Injuries/Poisoning/Pollutants 20-32 Immunology 21 Business Office Files--General View of Subjects Supported by the National Institutes of Health 1-4 Neuroscience 5-8 Genetics 9-10 Behavioral Biology 11-12 Cognitive Processes 13 Communications 14 Personalities 15 Roles 16 Adjustment and Stress 17 Interactive Behavior 18 Cultures and Customs 19 Social Mobility, Social Problems, and Social Behavior 20-22 Math and Statistics 23-24 Legal Manpower and Resources 25 Societal Programs for the Elderly 26 Socio-Economic Programs 27-28 Technology 22 Catalogues 1 Bellco Glass Inc. 2 BioQuest 3 Brinkmann Instruments 4 Chase Instruments 5 Cooke Laboratory Products 6 Corning Glass Works 7 Euro-Matic Balls 8 Falcon Products 9 International Biotechnologies Incorporated 10 LeeWards 11 Linbro Laboratory Aids 12 Mereck and Company 13 Metrohm AG 14 Malge Sybron Corporation 15 Scientemp Corporation 16 Volac 17 VWR Scientific 23 Conference and Seminar Files 1-7 Seminar Notes 1949-1951 8-10 Pediatric Seminar in England 1964 11 Lecture Notes for Atlantic City Conference 1969 12 Conference on Purine Metabolism and Gout 1974 13 Seegmiller's Group Seminars Winter Quarter 1975 14-21 Conference Notes 1974-1979

These were taken by various students and assistants.

 22-30 Diagnosis, Treatment, & Prevention of Genetic Diseases Seminar 1978 31 List of Seminars 1980 32 Development of the National Research Plan on Aging, Initial Editorial Group Meeting 1981 33 Fourteenth Annual Clinical Gerontology Lectures 1984 24 Conference and Seminar Files 1 Social Policy and the Economics of Aging: A Conference Monograph 1985 2-12 People to People Rheumatology Delegation in China 1985 13 Gordon Conference on Biology of Aging Notes 1986 14-21 Baltimore Longitudinal Study of Aging Conference 1986 25 Laboratory of Biological Chemistry Conference 1986 26 Conference and Seminar Files 1 Oxygen Radicals and Antioxidants in Cancer and Aging Workshop 1987 2-28 Laboratory of Cardiovascular Science Conference 1987 29-31 124th Annual Conference of the National Academy of Sciences 1987 27 Conference and Seminar Files 1-12 Laboratory of Molecular Genetics Conference 1988 13 43rd Annual Scientific Meeting, "Generations: Continuities, Conflicts, and Reciprocities" 1990 14 Recent Advances in Geriatric Medicine Conference 1991 15 6th International Symposium on Purine and Pyrimidine Metabolism Slides

These are copies. The originals are in Manuscripts Division Multimedia Section (P0622)

 28 Desk Material

To conserve space, only pages with information written on them were retained from the unbound desk calendars.

 1 Physician's Handbook 1944 2-3 Business Cards 4-7 Various papers, Receipts, and Tickets 8 Wall Decorations, Pictures, and Certificates 9 Desk Calendar 1968 10-12 Desk Calendar 1969 13 Pocket Calendar 1970 14-17 Desk Calendar 1970 18-21 Desk Calendar 1971 22-25 Desk Calendar 1972 26-29 Desk Calendar October 1973-January 1975 29 Desk Material 1-4 Desk Calendar 1978 5 Academic Year Weekly Minder 1978-1979 6-10 Desk Calendar 1979 11 Academic/Fiscal Planner 1979-1980 12-15 Desk Calendar 1980 16 Academic/Fiscal Planner 1980-1981 17-19 Desk Calendar 1981 20 Academic/Fiscal Planner 1981-1982 21-22 Desk Calendar 1982 23 Academic/Fiscal Planner 1982-1983 30 Desk Materials 1 Academic/Fiscal Planner 1983-1984 2-5 Desk Calendar 1984 6-8 Desk Calendar 1985 9 Academic/Fiscal Planner 1985-1986 10-11 Desk Calendar 1986 31 Illustration Files July 1966-December 1980

These folders contain charts, graphs, medical illustrations, photocopies of photographs and slides (the originals are in the Multimedia Section of the Manuscripts Division, P0622), transparencies, and tables. Some of the items in these illustration files were used in Seegmiller's papers, books, and lectures. These files are grouped as he left them, and arranged by date.

 32 Illustration Files January 1981-May 1988 1-17 Illustration Files January 1981-May 1988 18 Illustration Files, Miscellaneous or Unknown Years 33 Patient Related Files 1 Personal History of Khoa Doung 2 Medical History of Victor Gore 3 Medical History of Thomas Hooke 4 Frank E. Willie Medical Charts 5 Patient Information Booklet on Arthritis 6 Patient Concentration Levels 7 Doctor Lietman's Patient List 8 XYY Male Memo and Slides

Original slides in Manuscripts Division's Multimedia Section (P0622).

 34 Patient Related Files

Index cards of "Cell Types," "papers," and "Experiment Notes on Patients." ACCESS REQUIRES PERMISSION OF MANUSCRIPTS DIVISION HEAD.

 35 Patient Related Files, Index Cards of Patients by Disease

A white card (with cross-references) was made out for each disorder found in each patient on whom Dr. Seegmiller had a National Institute of Health, University of California Hospital, or outside patient file. A blue card is a duplication of the tissue culture laboratory's "Cell Types" file which lists the cultures grown of each disease. ACCESS REQUIRES PERMISSION OF MANUSCRIPTS DIVISION HEAD.

 36 Proposals and Reports 1 Report of the Task Group on Biohazard Control 1972 2-3 Genetic Research Report 1975 4 National Stable Isotopes Resource Report 1976 5-7 Three Drafts on a Report of Alkaptonuria/ochronosis 1987 8-14 Proposal on Patients with Dominantly Inherited Gouty Arthritis who are Heterozygote for Aldolase B Deficiency 1989 15-29 Report on Extending and Enhancing Life 1990 37 Specimen Records and Laboratory Office Files (A-C) 1-10 Alkaptonuria 11 John Allen Anderson Records 12 Bioassay Systems Information 13-17 Cell Records 18-20 Cell Repositories 21-24 Closed Business 1974-1975 25 Core Cell Culture Facility 26-28 Creatinine Values 29-30 Culture Records 1977 31 Current Research 1977 32 Cystinosis 38 Specimen Records and Laboratory Office Files (D-I) 1-4 Employee Time Records 5 Excretion Study Results 6 Fibroblast Correspondence 7 Flow Lab Inventory Sheets 8 Genetics Lecture Notes 1964-1965 9 Gout Material 10-13 Hippuric Acid Results 14-19 Irvine Scientific Results on Mycoplasma Tests 20-22 Isotope Studies 39 Specimen Records and Laboratory Office Files (J-L) 1-2 Laboratory Methods Manual 1947 3-7 Laboratory Methods Manual 1950 8-12 Laboratory Methods Manual 1955 13-18 Laboratory Methods Manual 1975 19-27 Lesch/Nyhan Syndrome Screening Tests 28-32 Lymphoblast Assay/Experimentation 40 Specimen Records and Laboratory Office Files (M-O) 1 Mass Spectrometer/Radioactivity Study 2 Nitrogen Urase Sample Notebook 3-30 Orders/Invoices 41 Specimen Records and Laboratory Office Files (P-Re) 1 Pedigree Charts and Information on McJunikin 2 Progeria Cultures 3-13 PRTase Studies Information 14 Record of Cells Sent Out of the Lab 15-25 Research papers 42 Specimen Records and Laboratory Office Files (Ro-So) 1 Rotenone Toxicity 2 Sample Records 1954-1960 3 Sample Records 1959 4-6 Sample and Supply Information 1976-1977 7-9 Self Absorption Curves 10 Sheep Red Blood Cell Experimentation Records 1978 11-13 Solubility Study Results 1961 43 Specimen Records and Laboratory Office Files (Sp-Z) 1 Specimen Records 1969 2-9 Specimen Records 1974-1975 10-19 Specimen Records 1976-1977 20 Testosterone, Deoxymethansone 21-23 Counting Uric Acid Molecules Results 24-30 Miscellaneous Lab Materials 44 Unidentified Notes

The materials in boxes 44-47 are notes taken during research and/or experiments. They contain charts, graphs, and handwritten notes. However, for most of these files, there is no indication of who did the research, when it was done, what it was, or why it was being done.

 45 Unidentified Notes 46 Unidentified Notes 47 Unidentified Notes III. Research Materials

The material contained in this section of the Collection pertains to information and reprints of articles used by Dr. Seegmiller in his publications and lectures. Boxes 48 and 49 contain material used in his various appearances as a lecturer, or when someone else that he knew wanted to use his material for one of their own lectures. Boxes 50 and 51 contain the research material and publications of Jarvis Edwin Seegmiller. On some of the writings Dr. Seegmiller was a co-author whose name is not listed first. Boxes 52 through 61 contain writings by some of Seegmiller's associates, and he used many of them on research for his own articles. Boxes 62 through 65 are Seegmiller's bibliographic reference system. Whenever he did research, he kept a bibliography of every source he used. Then, he put those sources on these cards; so that in the future, he could gain access to them easily.

 48 Research and Lecture Materials 1950-1980 1-8 Alcaptonuria 1951-1987 9 Anatomy Locator Note Cards 10-13 General Materials 1970-1972 14 General Materials 1973 15 General Materials 1981 16 General Materials 17-19 Homogentisic Acid 1961-1972 20-32 Lesch/Nyhan Syndrome 1960-1985 33-38 Spectrometer Data Sheets 1980 49 Research and Lecture Materials 1960-1985 1-3 Swiss Institute of Experimental Cancer Research 1983 4-10 Seegmiller's Second Paper on Uric Acid Concentrations 11-13 Joel Kaofamn, "Uric Acid In Adults With and Without Gout" 14-21 Dr. Grayzel, "Uricosuric Agents-Isotope Study"

Raw data. Unknown first name.

 22-23 Writings by Seegmiller and Others 1967-1969 50 Publications and Writings by Seegmiller 1948-1978 1-6 "Studies on Nitrogen Mustard" 1948 7-8 "The in vitro Effect of Insulin on the Metabolism of Pigeon Breast Muscle" 1948 9 "Incorporation of 4-Amino-5-Imidazolecarboxamide-4-C13 Into Uric Acid in the Normal Human" 1955 10 "An Enzymatic Spectrophotometric Method for the Determination of Homogentisic Acid in Plasma and Urine" 1960 11 Scientific Directory 1964 and Annual Bibliography 1963 1964, 1963 12 "Regulation of Purine Synthesis in Gout" 1966

Written in Spanish.

 13-16 "Diseases of Purine and Pyrimidine Metabolism" 1969 17 "Decreased Binding of C14-Homogentisic Acid induced by Ascorbic Acid in Connective Tissues of Rats with Experimental Alcaptonuria" 1970 18 "The Preparation and Identification of Various Adducts of Oxidized Homogentisic Acid and the Development of a New Sensitive Colormetric Assay for Homogentisic Acid"; Gout: A Clinical Comprehensive 1971 19 "Purine Metabolism in Normal and Thioguanine-Resistant Neuroblastoma" 1973 20-22 "Expression of Purine Overproduction in a Series of 8-Azaguanine-Resistant Diploid Human Lymphoblast Line"; "Pathophysiology of Purine Metabolism in Man"; "Diseases of Purine and Pyrimidine Metabolism" 1974 23 Contemporary Diagnosis/Management of Gouty Arthritis 1975 24-25 "Ouabain-resistant Human Lymphoblastoid Lines Altered in the (Na+and K+)-dependent ATPase Membrane Transport System"; "Disorders of Purine and Pyrimidine Metabolism" 1976 26-31 "Disorders of Purine and Pyrimidine Metabolism" 1977 32 "Collection and Uses of Lymphocyte Cultures" 1978 51 Publications and Writings by Seegmiller 1980 1 "Human Immunodeficiency Discases Associated with Defects in Purine Metabolism"; "An in Vivo and in Vitro Evaluation of 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamidine: An Inhibitor of Human Lymphoblast Purine Nucleoside Phosphorylase"; "Nucleotide and Nucleoside Metabolism and Lymphocyte Function" 1980 2-14 "A Simple Screening Test for the Lesch Nyhan Syndrome" 1980 15-16 "Gout" 17-22 "Primary Enzyme Defects Associated with Excessive Purine Synthesis and Gouty Arthritis" 23-27 "Diseases of Purine and Pyrimidine Metabolism"

Next to final draft.

 28 "Chronic Tophaceous Gout" 29-31 "Ratio of Urinary Uric Acid to Creatinine for Detection of a Familial Disease of Purine Metabolism and Central Nervous System Function" 52 Publications and Writings by Others on Arthritis and Gout 1 Medical Illustrations on Arthritis and Gout 2 Primer on the Rheumatic Diseases 1973 3 Workshop on Artificial Finger Joints 1969 4 Bulletin on Rheumatic Diseases 1954-1958 5 Arthritis, Rheumatic Diseases, and Related Disorders 1980 6 Arthritis Rounds 1972-1973 7-8 Arthritis and Rheumatism 1975-1976 9 "On the Metabolic Defect in Gout" 1952 10 Gout 1957 11 Gout: A Clinical Comprehensive 1971 12 Gout: A Lecture Outline with Slides 1974 13 Gout: A Management Update 1974 53 Publications and Writings by Others on Chemistry 1-2 General Publications in Chemistry 1948-1985 3 Physiological Chemistry and Physics 1971 4 Molecular Pharmacology 1974 5 Enzyme Kinetics 1974 6 "Separation and Analysis of Phosphorylated Intermediates" 1977 7 Chemical Antidepressant Therapy 1983 8 The Medical Letter Handbook of Drug Interactions 1983 9 "Clinical Biochemistry" 1983 10-12 Free Radical Biology and Medicine 1987 54 Publications and Writings by Others in a Foreign Language 1 Nutriciavademecum 1967 2 Jaarverslag 1968-1969 3 Informationen zer Kernforschung und Kerntechnik 1973 4-5 Acta Medica Auxologica 1974 55 Publications and Writings by Others on General Topics 1 List of Books Removed from Seegmiller's Office in 1982 1982 2 The Elder's Journal 1944 3 Public Health Care in the Netherlands 1953 4 A supplement on Artificial Respiration 1957 5 Current Research in the Netherlands 1969 6 Current Medical Digest 1969 7 Article on Cardiovascular Mortality 1969-1971 8 The Merck Manual 1972 56 Publications and Writings by Others on General Topics 1 Myology and Osteology of the Domestic Turkey 1973 2-3 Time 1973 4 Transplantation Reviews 1975 5 Cancer in Utah 1979 6 The San Diego Union newspaper 1983 7 Article on Carcinogenic Agents 1983 8 Physicians for the Twenty-First Century 1984 9 Promoting Health/Preventing Disease 1989 57 Publications and Writings by Others on Genetics 1 Expression of Human Adenosine Deaminase and Its Complexing Protein in Health and Disease 1952 2 "Disease States Exhibiting Visible Chromosomal Abnormalities" 3 British Medical Bulletin 1969 4 "Selected Screening Tests for Genetic Metabolic Diseases" 1969 5 Advances in Human Genetics and Their Impact on Society 1972 6 What are the Facts about Genetic Disease? 1974 7 Human Genetics Notes 1975 8 Technical Report #3--Computer Drawn Pedigrees 1977 9 Technical Report #7--Genealogy Data Interface 1978 10 Technical Report #8--Genealogy Input System 1978 11 "Genetics and Aging in Protozoa" 1981 12 The New Human Genetics 1981 58 Publications and Writings by Others on Genetics 1-32 "Prospects for Gene Therapy" 1982 59 Publications and Writings by Others on Genetics 1 Importance of Chromosomal Damage in Carcinogenesis 1983 2 "Altered Genetic Organization and Expression in Aging Human Fibroblasts" 1984 3 "Genetic Heterogeneity among Kindreds with Alport Syndrome" 1987 4 "Alport Syndrome" 1987 5 "Forever Young" 1987 6 "Mapping of Alport Syndrome" 1988 7-32 "Familial Alzheimer's Disease," Sections I-IV 60 Publications and Writings by Others on Immunology 1-3 Article Reprints 1947-1984 4 Immunological Reviews, Vol. 51 1980 5-6 "System for Automatic Peptide Analysis" 1972 7 Immunologic Aspects of Ultraviolet Carcinogenesis 1977 8 Basel Institute for Immunology Annual Report 1981 9 Basel Institute for Immunology Publications 1982 10 Formation an Excision of Cyclobutane 1983 11 The Antibody Response In Vitro 61 Publications and Writings by Others on Joint Disorders 1-12 "Studies of Joint Aging and Osteoarthritis" April 1991 62 Publications and Writings by Others on Joint Disorders 1-11 "Studies of Joint Aging and Osteoarthritis" July 1991 63 Publications and Writings by Others on Metabolism 1-9 Article Reprints 1944-1985 10 Symposium on Treatments of Amino Acid Disorders 1967 11 Idiopathic Neonatal Hypoglycemia 1969 12 Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency 1973 13-25 An Evaluation of Research Needs 1979 64 Publications and Writings by Others on Urological Studies 1 DeWitt Stetten, Jr. 1950-1953 2-9 P.H. Cerutti 1960-1986 10 Watts, Gibbs, and Purkiss 1983

Unknown first names.

 11 Aminoaciduria in Various Types of Rickets 1960 12 An Annotated Bibliography of Low Molecular Weight Constituents of Human Urine 1968 13-23 DeWitt Stetten's Reprints 65 Bibliography Subject Index Cards (A-E) 66 Bibliography Subject Index Cards (F-K) 67 Bibliography Subject Index Cards (L-R) 68 Bibliography Subject Index Cards (S-Z) IV. Experimental Research Notebooks

Dr. Seegmiller kept detailed notes on all of his procedures and experiments, and these notebooks are contained in boxes 69 through 109. Boxes 110 through 131 contain the laboratory notes of Dr. Seegmiller's assistants and/or students. These notebooks are arranged in alphabetical order by the last name of the author. If there is more than one book written by the same person, those books are arranged in chronological order.

 69 Seegmiller's Notebooks 1946-1949 1 Diphosphothiamin #1 1946 2 Chronic Carbohydrates 1949 3 Phosphogluconate Dehydrogen #1 1949 70 Seegmiller's Notebooks 1950-1951 1 Laboratory Methods 1950 2 Laboratory Procedures 1950 3 Solubility of Glucose 6 Phosphate, Book I 1950 4 Solubility of Glucose 6 Phosphate, Book II 1950 5 Acid Dehydration 1951 71 Seegmiller's Notebooks 1951-1952 1-5 Glycogen Storage Disease and Gout 1951 6-19 Acetate Tests #1 1950-1952 20 Lactic Dehydrogenase 1952 21 Paroxysmal Enzyme 1952 72 Seegmiller's Notebooks 1953-1954 1 Ethyl Forminoellum Hydrochloric Acid 1953 2 Glycine Studies, C13AIC + N15, #4 1953 3 Properties of 4-Aminoimidazole #2 1953 4 Xanthine Oxidase Uricase 1953 5 AIC plus Glycine 1954 6 Creatinine #1 1954 7 Mass Spectrophotometry 1954 73 Seegmiller's Notebooks 1954-1955 1-4 Mass Spectrometer Samples #29-32 1954 5-6 Multidimensional Notes 1954 7 N15 Glycine Study G 1954 8 Uric Acid #1 1954-1955 74 Seegmiller's Notebooks 1955 1 Clinical Studies 1955 2-4 Creatinine 1955 5 Gouty Arthritis and Administration of Isotopes 1955 6 Isotope Data 1955 7 Mass Spectromocy 1955 8 Nucleic Acid Purines 1955 75 Seegmiller's Notebooks 1955 1 Synthesis of Uric Acid 1955 2 Uric Acid #2 1955 3-23 Uric Acid and Creatinine Analysis #1 1955 76 Seegmiller's Notebooks 1955-1956 1 Uric Acid and Creatinine Analysis #2 1955 2 Creatinine #2 1955 to 1956 3 Glycine Administration 1955 to 1956 4 Uric Acid #3 1955 to 1956 5 AIC 1956 6-12 Allantoxin Method 1956 77 Seegmiller's Notebooks 1956 1 Carbon-14 Scintillator 1956 2 Cholesterol Metabolism 1956 3 Clinical Studies 1956 4 Course Notes on Biochemical Genetics 1956 5 Creatinine #3 1956 78 Seegmiller's Notebooks 1956 1 Glucose Assay 1956 2 Glycine C 13 and N13 1956 3 Gout and Purine Metabolism 1956 4 Homogentsinic Acid Isolation 1956 5 Ochronosis 1956 6 Uric Acid 1956 79 Seegmiller's Notebooks 1956-1957 1-16 Calculations of Uric Acid and Creatinine #2 1956-1957 17 Uric Acid #4 1956-1957 18 Alcaptonuria #1 1957 19 Alcaptonuria #2 1957 80 Seegmiller's Notebooks 1957 1 Alcaptonuria #3 1957 2 Clinical Studies of Turner Burgess 1957 3 Creatinine #4 1957 4 Forminoglutamic Acid Assay 1957 5 Homogentisic Acid Isolation and Briggs Analysis 1957 6 Uric Acid #5 1957 81 Seegmiller's Notebooks 1957-1962 1-16 Uric Acid and Creatinine Analysis #3 1957-1959 17 AIC Tolerance Tests 1957-1962 18 Creatinine #5 1958 19 Rat Thiadiazole 1958 82 Seegmiller's Notebooks 1958-1959 1 Uric Acid #4 1958 2 Uricase Inhibitor 1958-1959 3-6 AIC Incorporation into Purines 1958-1959 83 Seegmiller's Notebooks 1959 1-2 6-Chlorouric Acid 1959 3 Alcaptonuria 1959 4 Ammonia Determination 1959 5 Immunology 1959 6 Potassium Glutamate 1959 84 Seegmiller's Notebooks 1959-1960 1 Uric Acid #7 1959 2-8 Uric Acid and Creatinine Analysis #4 1959 9 Creatinine #6 1959-1960 10-16 Uric Acid 1959-1960 85 Seegmiller's Notebooks 1960 1 Connective Tissue Biochemistry 1960 2 Cystinosis #1 1960 3 Cystinosis #2 1960 4-8 Excretion in Cystines 1960 9-14 Organic Acids 1960 86 Seegmiller's Notebooks 1960 1 Renal Excretion #1 1960 2-8 Uric Acid #8 1960 9 Uric Acid and Creatinine Mass Spectroscopy 1960 10-12 Urinary Cystines 1960 87 Seegmiller's Notebooks 1960-1962 1 Creatinine #7 1960-1961 2 Uric Acid 1960-1961 3-11 Urine Insulin 1960-1962 12-15 Clinical Studies in Cystinase #4 1961-1962 16-22 Sulfate Studies in Cystinase #3 1961-1962 88 Seegmiller's Notebooks 1961-1964 1-7 Uric Acid #9 1961-1962 8 Creatinine #8 1961-1963 9 Urate Solubility 1961-1964 89 Seegmiller's Notebooks 1962 1 Glucose and Lactose and Glycogen Storage 1962 2 Kreb's Ringer Phosphate 1962 3 Phagocytosis Studies 1962 4-10 Uric Acid #10 1962 11-18 Urine Insulin 1962 90 Seegmiller's Notebooks 1962-1967 1 Glycogen Storage Disease 1962-1963 2-9 Lactates and Pyruvates 1962-1963 10 Skin Tests 1962-1967 11 Uric Acid #11 1962-1963 91 Seegmiller's Notebooks 1963 1 Creatinine #9 1963 2 Cystine Isolation 1963 3 "Feedback" Clinical Study 1963 4-7 Lietman Cystinosis 1963 8 Nucleotide Studies in Human Liver and Gout 1963 9 Oxypurines 1963 10-17 Oxypurines #2 1963 92 Seegmiller's Notebooks 1963 1-8 Oxypurines #5 1963 9-13 Patient Data on Cystinosis 1963 14 Purine Chromatography 1963 15 Purine Free Diet Results 1963 16 Urate Crystals Metabolism Effect on Gout 1963 93 Seegmiller's Notebooks 1963 1 Uric Acid 1963 2-10 Uric Acid #12 1963 11-13 Xanthinuria 1963 94 Seegmiller's Notebooks 1963-1966 1-12 Oxypurines 1963-1966 13 Patient's Fluids Journal 1963-1964 14-21 Uric Acid #13 1963-1964 95 Seegmiller's Notebooks 1964 1 Acute Gout 1964 2 Assay for Kynureninase Activity 1964 3-6 Cystine Isolation 1964 7 Renal Clearance #2 1964 8 Synthesis of Alpha-Keto Beta-methyl Valeric Acid 1964 96 Seegmiller's Notebooks 1964 1-2 Urate Determinations 1964 3 Uric Acid, Xanith, and Hypoxautl Solubility 1964 4 Xanthinuria Isolation 1964 97 Seegmiller's Notebooks 1965-1966 1 Glycogen Storage 1965 2 Uric Acids Miscellaneous 1965 3 Carboxyl Peptidase 1965-1966 4-10 Uric Acid #14 1965-1966 98 Seegmiller's Notebooks 1966 1-13 Amino Acid Analysis 1966 14 Metabolic Diseases 1966 15 Oxypurines 1966 99 Seegmiller's Notebooks 1966 1-7 Oxypurines 1966 8-14 Uric Acid #15 1966 100 Seegmiller's Notebooks 1966-1967 1-13 Amino Acid Analysis 1966-1967 14-26 Isotope Studies #4 1966-1967 101 Seegmiller's Notebooks 1966-1969 1 Phosphoribosyltransferase 1966-1967 2 Urate Injections and Skin Tests 1966-1969 3-11 Uric Acid, Creatinine, and Urinary Oxypurines #1 1966-1967 102 Seegmiller's Notebooks 1967-1969 1 Blood Enzymes 1967 2 Heterozygosity Test by Mosaicism Defection in Red Blood Cells 1967 3 Proteins 1967 4 Urine Screening 1967 5-10 Uric Acid and Creatinine Analysis #5 1967-1968 11 PRT Assay Methods 1967-1969 103 Seegmiller's Notebooks 1968-1969 1 Cell Cultures Passage History 1968 2 Fibroblasts and Xanthine Study 1968 3-6 Log Book of Cell Records #2 (K-Q) 1968 7-9 Log Book of Cell Records #3 (R-Z) 1968 10-12 Veteran's Association Mannitol Study 1968 13-22 Uric Acid and Creatinine #6 1968-1969 104 Seegmiller's Notebooks 1969-1970 1-6 Log Book on Cheryl Mann Data 1969 7 Stand Solutions for Lowery Deformation 1969 8 Biochemical Technique of Purine Metabolism 1970 9 Chymolinypsin 1970 10-13 General Notes and Mixed Material 1970 105 Seegmiller's Notebooks 1972-1973 1-6 Experiments with Nucleotides 1972 7 Log Book of Media used in Samples 1972-1973 8-10 Cell Extractions Experiment 1973 11 Twelve Photographs of Cells and Fibroblasts 1973

Originals in the Manuscripts Division Multimedia Section (P0622)

 106 Seegmiller's Notebooks 1974 1-3 Biochemical Assay 1974 4-24 Uric Acid, Creatinine, and Oxypurines #2 1974 107 Seegmiller's Notebooks 1974-1977 1-5 Log Book of Clinical Specimens 1974-1976 6-10 Uric Acid, Creatinine, and Oxypurines #3 1974-1977 11 Adenosine Concentrations 1975 12-13 Basel Institute for Immunology #1 and #2 1975 14-16 Miscellaneous Notes 1975-1976 17 Sample Log Book 1975-1977 18 Duri School of Pathology 1976 19-22 Growth Factor Experiment 1976 108 Seegmiller's Notebooks 1976-1983 1 Multiple Experiment Lab Notebook 1976-1983 2 Lowery Protein Determination Method Experiment 1977 3 Basel Institute for Immunology 1980 4 Endo Nucleotidase Freeze and Thaw Lysis of Cells 1980 5 Nucleotides Calculator Programming and Lymphoblast Assay 1980 6-10 Lab Notebook from Sabbatical Lausane, Switzerland 1982-1983 109 Seegmiller's Notebooks 1983-1986 1 Alzheimer: Genetic and Biochemical Factors #2 1983-1986 2-3 Enzymatic Assay of Adenosine Deaminase and Laboratory Protocols 1986 4 Uricase Inhibitor 110 Lab Notebooks of Assistants and Students (A-As) 1 Adelson, Gary 1973 2 Argubright, Kent 1972 3-6 Astrin, Ken 1969-1970 111 Lab Notebooks of Assistants and Students (As) 1-10 Astrin, Ken 1970-1972 11-17 Astrin, Ken--Notebook Insertions 1971-1973 112 Lab Notebooks of Assistants and Students (As) 1-4 Astrin, Ken 1971-1973 5 Astrin, Ken 113 Lab Notebooks of Assistants and Students (B-D) 1-3 Boyle, James 1959-1969 4 Briston 1967-1969 5 Cracaw, Mickey 1963-1976 6 Cruikshank, Mike 1975 7 Dauenheimer, S. 1962 114 Lab Notebooks of Assistants and Students (E-F) 1 Epstein, Charles 1967 2-5 Fujimoto, W. 1967-1969 115 Lab Notebooks of Assistants and Students (G-Go) 1 Goldfinger, Stephen--Acute Gout 1961 2-20 Goldfinger, Stephen--Excretion Studies (Subjects A-L) 1964 116 Lab Notebooks of Assistants and Students (Go) 1-21 Goldfinger, Stephen--Excretion Studies (Subjects L-Z) 1964 22 Goodsell, Neil 1956 117 Lab Notebooks of Assistants and Students (Gr-Gu) 1 Graf, Marsha 2-6 Grayzel 1951 7-8 Greene, Martin 1967-1969 9-10 Gubler, Clark 1972 118 Lab Notebooks of Assistants and Students (Gu-He) 1-2 Gubler, Clark 1972-1976 3-4 Henderson, Frank 1966-1967 5 Hershfield, Michael 1975-1977 119 Lab Notebooks of Assistants and Students (Ho-Hr) 1-5 Howell, Rodney 1960-1962 6-7 Hryushihwa, D. 1968 120 Lab Notebooks of Assistants and Students (J) 1-2 James, Jeanette 1973-1977 121 Lab Notebooks of Assistants and Students (Ja) 1-13 Jansen, Inga #1 1969-1973 14-24 Jansen, Inga #2 1973 122 Lab Notebooks of Assistants and Students (Ja) 1-10 Jansen, Inga #3 1973-1974 11-13 Jansen, Inga #4 1974 14-20 Jansen, Inga #5 1975-1976 123 Lab Notebooks of Assistants and Students (Ja) 1-17 Jansen, Inga #6 1978 18-26 Jansen, Inga #7 1978 124 Lab Notebooks of Assistants and Students (Ja) 1-12 Jansen, Inga #8 1975-1978 13-22 Jansen, Inga #9 1975-1978 125 Lab Notebooks of Assistants and Students (K-Ke) 1 Kaufman 1967 2-4 Keefer 1968 5 Kelley, W. N. 1966 126 Lab Notebooks of Assistants and Students (Ke-Ko) 1-11 Kelley, W. N. 1966-1967 12 Kowitt, Frances 1959-1960 127 Lab Notebooks of Assistants and Students (L-M) 1-2 Laster, Leonard 1954-1957 3 Lever, Julia 1972 4 Mathews, Gunther 1967 5 Miller, J. 1964 128 Lab Notebooks of Assistants and Students (P-PI) 1 Phillips, Cynthia 1967-1968 2-6 Plato, Candace 1960-1961 129 Lab Notebooks of Assistants and Students (PI-S) 1-4 Plato, Candace 1961-1962 5-6 Rosenbloom 1965-1967 7 Schneider 1965-1966 8 Schulman, J., and T. Lustberg 1968 130 Lab Notebooks of Assistants and Students (W-We) 1 Wallace, Jeanette 1978-1979 2-5 Watts, R. W. E. 1963 6 Watts, J. E. M. and Jarvis Seegmiller 1968 131 Lab Notebooks of Assistants and Students (Wh-Y) 1-4 White, John S. 1972 5 Yates, Robert 1970 132 Oversize Documents

This box contains architectural drawings of the rooms in which Dr. Seegmiller conducted his experiments (which were remodeled for his own use) at the National Institutes of Health. The ideas and notes for these renovations can be found in Seegmiller's Business Office Files; (box 8, folders 2-6).

 V. Addendum 1996

These papers (1969-1988) were donated in August 1996 by Dr. Seegmiller to be added to his previous Collection, and they are a supplementation to Section Two, Office Files. Box 133 contains general office material such as notes, correspondence, awards, class reunions, information on visiting professors, and equipment instructions. Boxes 134-138 contains the paperwork for the federal grant programs awarded to Seegmiller and his team at the University of California, San Diego (UCSD). The largest portion of these files are related to the grant for the Human Biochemical Genetics Program (HBGP). These files are organized by each of the twelve years that this grant was awarded, and then followed by miscellancous material related to the program. Boxes 139-164 contains correspondence, pamphlets, programs, abstracts, related articles, and lecture notes for the different conferences, symposiums, and annual group meetings upon which Seegmiller received information. For many of these, Seegmiller gave a lecture on gout, metabolism, or geriatric health care.

 133 Business Office Files 1 Air Flight Information 1976 2 Correspondence 1972-1987 3 Department of Health, Education, and Welfare 4 Distinguished Service Award May 15, 1980 5 Extraction Procedures for Liquid Chromatography 6 Liquid Chromatography of Nucleotides 7 Personal London Trip Information 1975 8-10 Practical Chromatography Notes 11 Purine Levels 12-13 Research Articles on Hypoxanthine-Guanine By Others 14 Daniel Steinberg's Writings 15 University of Chicago, Twenty-fifth Class Reunion June 7, 1973 16 Urine Testing in Liquid Chromatography 17 Visiting Professor Material at the University of Cincinnati Medical Center 1976 18 Visiting Soviet Scientists to UCSD November 12, 1973 134 Federal Grant Projects 1-8 Grant UCSD #87-6040, Specialized Center of Research on Osteoarthritis September 1987-August 1992 9-17 Human Biochemical Genetics Program (HBGP), Year One, Grant Application, Grant # GM17702 1970 18 HBGP, Year One, Preparation 19 HBGP, Year One, Revised Budget 20 HBGP, Year One, Correspondence 21 HBGP, Year One, Notice of Grant Awarded/Report of Expenditures 22 HBGP, Year Two, Preparation 23 HBGP, Year Two, Notice of Grant Awarded/Report of Expenditures 24 HBGP, Year Two, Correspondence 135 Federal Grant Projects 1-5 HBGP, Year Two, Continuation of Application 6 HBGP, Year Three, Preparation 7 HBGP, Year Three, Notice of Grant Awarded/Report of Expenditures 8 HBGP, Year Three, Correspondence 9 HBGP, Year Three, Site Visit August 21, 1972 10 HBGP, Year Three, 1975-1980 Renewal Planning Session 1973 11-12 HBGP, Year Three, Request for Extramural Support 13-15 HBGP, Year Four, Preparation 16 HBGP, Year Four, Notice of Grant Awarded/Report of Expenditures 17 HBGP, Year Four, Correspondence 18-20 HBGP, Year Four, Site Visit January 28-29, 1974 21-24 HBGP, Year Five, Grant Application 1975-1980 25 HBGP, Year Five, Nyhan Project 26 HBGP, Year Five, Seegmiller Project 136 Federal Grant Projects 1-4 HBGP, Year Five, Schneider Project 5-6 HBGP, Year Five, Budget Statements 7-9 HBGP, Year Five, Core Facility A 10-12 HBGP, Year Five, Correspondence 13 HBGP, Year Five, Monthly Meeting Notes 14 HBGP, Year Five, Notice of Grant Awarded/Report of Expenditures 15 HBGP, Year Five, Workshop September 4-7, 1975 16-21 HBGP, Year Six, Preparation 22 HBGP, Year Six, Didactic Session 23-24 HBGP, Year Six, Anniversary Planning 137 Federal Grant Projects 1-8 HBGP, Year Six, Notice of Grant Awarded/Report of Expenditures 9-10 HBGP, Year Six, Correspondence 11-13 HBGP, Year Seven, Notice of Grant Awarded 14 HBGP, Year Eight, Notes 15-17 HBGP, Year Eight, Proposal Review 18 HBGP, Year Eight, Correspondence 19-22 HBGP, Year Nine, Application for Continuation 23 HBGP, Year Nine, Correspondence 138 Federal Grant Projects 1 HBGP, Year Ten, Application for Continuation 2 HBGP, Year Ten, Notice of Grant Awarded 3 HBGP, Year Eleven, Summary Statement of Application Review 4 HBGP, Year Twelve, Continuation Application 5-6 HBGP, Year Twelve, Progress Report 7 "Facts about the Human Biochemical Genetics Program at the University of California San Diego, "by J.E. Seegmiller 8 HBGP, First Wednesday of Month Seminars, Commencing May 4th, 1977 9 HBGP, Human Gene Map 10 HBGP, Personnel List 1976-1977 11 HBGP, Miscellaneous Material 12 HBGP, Initial Site Visit December 1969 139 Conferences, Seminars, and Lectures 1973 1-7 Yale Site Visit, Division of Research Resources, General Clinical Research Centers Branch January 4-6, 1973 8 National Institutes of Health, International Fellowship Review Committee, Winter Meeting January 29-30, 1973 9 Western Association of Physicians Meeting January 31, 1973 10 American Federation for Clinical Research, Section Meeting February 1-3, 1973 11 National Cystic Fibrosis Research Foundation February 8, 1973 12 Cystic Fibrosis Research Foundation Lecture March 6, 1973 13 Sigma Kappa Sorority Alumni Lecture March 14, 1973 14 Tissue Culture Association, California Chapter, Twelfth Symposium March 17, 1973 15 Roche Institute of Molecular Biology April 12-13, 1973 16-17 American College of Physicians, Annual Meeting April 9-13, 1973 140 Conferences, Seminars, and Lectures 1973 1 American Society of Biological Chemists, Annual Meeting April 15-20, 1973 2 Hospital Laboratory, European Conference April 23-May 7, 1973 3 Gene Localization and the Biochemical Basis of Gene Regulation in Mammalian Cells, Seventh Basel Colloquium April 25-27, 1973 4 American Federation for Clinical Research, Annual Meeting April 28-29, 1973 5 American Society of Clinical Investigation, 65th Annual Meeting April 30, 1973 6 Association of American Physicians, Annual Meeting May 1-2, 1973 7 American Association of Clinical Chemists, Conference on Amniotic Fluid May 11-12, 1973 8 Cystic Fibrosis Club, Annual Meeting May 15, 1973 9-10 University of Texas, Southwestern Medical School, Faculty Seminar May 23, 1973 11 "Inborn Errors of Metabolism," American Association of Clinical Chemists Symposium May 26, 1973 12 Control and Diagnosis of Genetic Disease Lecture June 11, 1973 13 Symposium on Prospects for Hereditary Metabolic Disease Control June 7-9, 1973 141 Conferences, Seminars, and Lectures 1973 1-3 International Symposium on Purine Metabolism in Man June 17-23, 1973 4 Jet Propulsion Laboratory Workshop, Caltech July 20, 1973 5 National Institutes of Health, 20th Anniversary of the Clinical Center July 6, 1973 6 Course in Human Genetics for Physicians and Scientists July 22-27, 1973 7 International Genetics Federation, Thirteenth Congress of Genetics August 20-29, 1973 8 Jet Propulsion Laboratory Lecture September 7, 1973 9 University of California, San Diego, Department of Medicine, Teaching Retreat September 7, 1973 10 International Congress of Rheumatology September 30-October 6, 1973 11 Roche Institute of Molecular Biology Meeting October 19-2, 1973 12 National Academy of Sciences, Autumn Business Meeting October 22-23, 1973 142 Conferences, Seminars, and Lectures 1973-1974 1 Scientific Advisory Committee Meeting, The Hospital for Sick Children October 22-23, 1973 2 American Society of Human Genetics, 25th Anniversary Meeting October 24-27, 1973 3 American Society of Human Genetics, Conference October 24-27, 1973 4 American Society of Human Genetics, Board Meeting October 25, 1973 5 National Cystic Fibrosis Research Foundation, Research Committee Meeting November 5-6, 1973 6 National Advisory General Medical Sciences Council Meeting November 28-29, 1973 7 Society of Graduate Internists December 7-8, 1973 8 University Hospital Auxiliary Health Education Lecture January 28, 1974 9 American Cancer Society Meeting of Fellowship Screening Committee January 9-11, 1974 10 Seminar on Purine Metabolism January 17, 1974 11 San Diego Area Chapter of the Arthritis Foundation, 25th Anniversary Meeting February 1, 1974 12 Western Association of Physicians Meeting February 6, 1974 13 American College of Physicians, Regional Meeting, Town and Country Hotel February 23, 1974 14 Mayo Clinic, Balfour Visiting Professor of Medicine February 27-March 3, 1974 15 California Medical Association Meeting March 2, 1974 16 Medical Advisory Board Meeting, The Hospital For Sick Children March 4-5, 1974 17 Mammalian Mutant Cell Line Committee Meeting, and Obtaining a Sample from M. Perkins March 11, 1974 18 Pan-American Health Organization, Study of Longevity with Dr. A. Leaf March 14-23, 1974 19 National Advisory General Medical Sciences Council Meeting March 27-29, 1974 143 Conferences, Seminars, and Lectures 1974 1-2 American College of Physicians, Meeting April 1-4, 1974 3 Scientific Advisory Committee, The Hospital for Sick Children April 4-5, 1974 4 Federation of American Societies for Experimental Biology, Annual Meeting April 8-12, 1974 5 National Academy of Sciences, Spring Meeting April 21-27, 1974 6 Roche Institute of Molecular Biology, Spring Meeting April 25, 1974 7 Seminar on Human Mutations in Purine Metabolism at Columbia University April 26, 1974 8 Cystic Fibrosis Club, Fifteenth Annual Meeting, National Cystic Fibrosis Research Foundation April 30, 1974 9 University of North Carolina Lecture May 1-3, 1974 10 American Federation for Clinical Research, National Meeting May 4-5, 1974 11 American Society of Clinical Investigation Meeting May 6, 1974 12 Association of American Physicians General Session May 6, 1974 13 Association of American Physicians Meeting May 7, 1974 14 Kroc Foundation Conference on Hyperuricemia and Gout May 19-22, 1974 15 Grand Rounds at South Central Community Hospital May 28, 1974 16 National Advisory General Medical Sciences Council Meeting May, 1974 17 American Society of Biological Chemists Annual Meeting June 2-7, 1974 18-19 National Institutes of Health, Director's Advisory Committee Meeting June 17-18, 1974 144 Conferences, Seminars, and Lectures 1974 1-3 Sixth Pan-American Congress on Rheumatic Diseases June 16-21, 1974 4 National General Medical Sciences Council (NGMSC), Advisory Committee Meeting June 23-25, 1974 5 Second International Congress of Immunology July 21-26, 1974 6 Given Institute of Pathology Conference July and August, 1974 7 "Management of Gout," Sharp Hospital Lecture August 14, 1974 8 12th International Congress for Fat Research September 2-7, 1974 9 Los Angeles County Medical Association Cruise September 15-30, 1974 10 Fallbrook Health Seminar, Potter Junior High School October 2, 1974 11 Fairview State Hospital, Research Consultants Meeting October 7, 1974 12 National Institute of General Medical Sciences, Anesthesiology Workshop October 10-11, 1974 13 American Society of Human Genetics, Meeting October 16-19, 1974 14 National Institute of Mental Health, Board of Scientific Counselors October 25-26, 1974 15 National Cysitc Fibrosis Research Foundation, Research Committee Meeting October 28-30, 1974 16 Lecture on Gout for the first year of Introduction to Clinical Medicine November 16, 1974 17 Visiting Committee to Study and Evaluate the Drug Research Board Meeting November 18, 1974 18 Symposium on Metabolic Arthropathies, University of Cincinnati Medical Center November 21-22, 1974 19 Roche Institute, Board of Scientific Advisors, Fall Meeting November 21-22, 1974 20 National Advisory General Medical Sciences Council Meeting November 26-27, 1974 21 Third Western Regional Conference on Rheumatic Disease December 13-14, 1974 145 Conferences, Seminars, and Lectures 1975 1 American Cancer Society Fellowship, Screening Committee January 9, 1975 2 Drug Research Board Review Committee Meeting January 22-23, 1975 3 Western Association of Physicians Meeting February 5, 1975 4 Working Group Meeting February 6-7, 1975 5 American Federation for Clinical Research, Western Section Meeting February 6-8, 1975 6 Twelve-Thirty Club of La Jolla Lecture February 20, 1975 7 "The Process and Treatment of Aging," Vista Hill Foundation, National Seminar February 21-22, 1975 8 "Uric Acid and the Urologist," Basic Urology Seminar Series Lecture March 10, 1975 9 Visiting Committee to Study and Evaluate the Drug Research Board March 13-14, 1975 10 Fairview State Hospital, Research Committee Meeting March 18, 1975 11 San Diego Rheumatism Society, Organizational Meeting March 19, 1975 12 "New Concepts of Human Hereditary Disease," Palomar College March 19, 1975 146 Conferences, Seminars, and Lectures 1975 1 National Advisory General Medical Sciences Council Meeting March 25-26, 1975 2 Subcommittee Meeting on Urolithiasis April 1, 1975 3 Roche Institute, Board of Scientific Advisors, Spring Meeting April 3-4, 1975 4-5 Japan Medical Congress, 19th General Assembly April 5-7, 1975 6 American College of Physicians, 56th Annual Session April 7-10, 1975 7 American Society of Biological Chemists, Annual Meeting April 13-18, 1975 8 Cystic Fibrosis Club, 16th Annual Meeting April 15, 1975 9 West Coast Regional Developmental Biology Conference April 17-20, 1975 10 National Institutes of Health, First Alumni Reunion April 19-20, 1975 11 National Academy of Sciences, Annual Meeting April 21-23, 1975 12 "Metabolic Basis of Inherited Disease," Medical Institute April 28, 1975 13-14 American Society of Clinical Investigation Annual Meeting May 3-5, 1975 15 "Contributions of Gout and the Lesch-Nyhan Syndrome to New Medical Concepts," Symposium Interdiciplinaire Sur L'Hyperuricemic May 16-17, 1975 16 International Symposium on Amino Acid Transport and Uric Acid June 1975 17 American Rhcumatic Association, Annual Business and Scientific Meetings June 1-6, 1975 147 Conferences, Seminars, and Lectures 1975-1976 1 "Advances in Our Understanding of Arthritis," Patrick Henry High Lecture June 9, 1975 2 National Advisory General Medical Sciences Council Meeting June 16-17, 1975 3 Pacific Slope Biochemical Conference June 16-18, 1975 4 "An Evening with the School of Medicine" June 18, 1975 5 "Genetic Disease and You," Agencies of the Combined Health Agencies Drive Lecture June 18, 1975 6 Huntington Memorial Hospital, Grand Rounds July 26, 1975 7 Given Institute of Pathobiology, Developmental Genetics Seminar and Chromosome Banding Workshop July 6-18, 1975 8 Medical Genetics Annual Seminar July 6-12, 1975 9 IUPAC Congress July 6-11, 1975 10 "Biochemical Genetics of Human Disease," Institute of Pathobiology Conference July 8, 1975 11 Diabetes Foundation Lecture, Canceled 1975 12 American Society of Human Genetics, Annual Meeting October 8-11, 1975 13 Conference on Pseudogout and Pyrophosphate Metabolism October 19-21, 1975 14 Malthe Foundation Lecture November 12, 1975 15 HBGP, Year Five, Fall Symposium November 14, 1975 16 National Advisory General Medical Sciences Council Meeting November 19-21, 1975 17 Fourth Western Regional Conference on Rheumatic Disease December 5-6, 1975 18 American Federation for Clinical Research, Western Section Meeting February 4-6, 1975 19 Basic Science Seminar Spring 1976 20 National Advisory General Medical Sciences Council Meeting March 24-25, 1976 21 International Symposium on Urolithiasis Research March 29-April 1, 1976 22 Lega Italiano Contro I Reumatismi Meeting April 4-5, 1976 23 American College of Physicians, 57th Annual Meeting April 5-8, 1976 24 American Federation for Clinical Research, National Meeting May 1-2, 1976 25 American Society of Clinical Investigation, Annual Meeting May 3, 1976 26 Association of American Physicians, Annual Meeting May 4, 1976 27 First International Clinical Genetics Seminar May 5-6, 1976 28 European Society of Human Genetics, Annual Meeting May 8-9, 1976 29 Eleventh Annual Meeting of the United States Public Health Service, Professional Association May 26-29, 1976 30 Second International Symposium on Purine Metabolism June 20-26, 1976 31 American Rheumatic Association, Annual Scientific Meeting June 8-12, 1976 32 American Society of Biological Chemists, 67th Annual Meeting June 6-10, 1976 148 Conferences, Seminars, and Lectures 1976-1977 1 CIBA Foundation Symposium on Purine and Pyrimidine Metabolism June 9-11, 1976 2 Society for the Study of Inborn Errors of Metabolism Meeting July 14-16, 1976 3 Texas Club of Internists Meeting October 6, 1976 4 National Advisory General Medical Sciences Council Meeting October 6-7, 1976 5-6 International Congress of Human Genetics, Annual Meeting October 10-15, 1976 7 Perinatal Symposium October 25-26, 1976 8-9 HBGP, Year Six, Fall Symposium November 15, 1976 10 Regional Conference on Rheumatic Disease, Islandia Hyatt House November 19-20, 1976 11 "Aberrations of Purine Metabolism in ID" November 29, 1976 12 "Diagnosis in Utero" January 17, 1977 13 "Inborn Errors of Metabolism" January 22, 1977 14-16 "Topics in Internal Medicine" January 24, 1977 17-21 National Advisory General Medical Sciences Council Meeting February 3-4, 1977 149 Conferences, Seminars, and Lectures 1977 1 California Hospital Association Convention February 22, 1977 2 "New Trends in Geriatric Care" March 14-16, 1977 3 "Defects in Purine Metabolism Associated with Human Immuno-Deficiency Disease" March 15, 1977 4 "Century Club" March 25, 1977 5 American Society of Biological Chemists, 68th Annual Meeting April 3-7, 1977 6 National Institutes of Health, Meeting on Urolithiasis April 13-15, 1977 7 American College of Physicians, 58th Annual Meeting April 18-21, 1977 8-11 National Academy of Sciences Meeting April 24-27, 1977 12 Eleanor Roosevelt Institute of Cancer Research Seminar on Aberrations of Human Purine Metabolism April 22, 1977 13 "Regulation of Purine Metabolism," Yale University Seminar April 28, 1977 14 Association of American Physicians, American Society of Clinical Investigation, and American Federation for Clinical Research Combined Meeting April 30-May 2, 1977 15 "Gout," Pathophysics Lecture May 2, 1977 16 Roche Institute of Molecular Biology, Tenth Anniversary Ceremonies May 20, 1977 17 Fourth Conference of LaJolla Immunologists May 22-25, 1977 18-19 National Institute of General Medical Sciences, Meeting May 25-26, 1977 20-21 National Advisory General Medical Sciences Council, Annual Meeting May 25-26, 1977 150 Conferences, Seminars, and Lectures 1977 1 National Institutes of Health, Meeting on Urolithiasis June 7-9, 1977 2 Genetics Center, Directors Meeting June 13-14, 1977 3-8 International Symposium on Inborn Errors of Metabolism in Man June 19-25, 1977 9 Fourteenth Congress of the International League Against Rheumatism June 26-July 1, 1977 10 Fourteenth International Congress of Rheumatology June 26-July 1, 1977 11 Genetics Training, Grants Presentation August 23, 1977 12-13 National Institute of General Medical Sciences and Subcommittee, Annual Meeting August 26-27, 1977 14 The Society for the Study of Inborn Errors of Metabolism, Annual Meeting September 11-15, 1977 15 Veterans' Administration Hospital, Site Visit September 19, 1977 16 Human Biochemical Genetics Program Semi-Annual Symposium September 30, 1977 151 Conferences, Seminars, and Lectures 1977-1978 1 University of California, San Diego, Cancer Center Site Visit October 3-4, 1977 2 American Society of Human Genetics Conference October 19-22, 1977 3 Grand Rounds at St. Joseph's Hospital November 18, 1977 4 National Institute of General Medical Sciences Conference October 30 - November 1, 1977 5 American Social Cell Biology Convention November 15-18, 1977 6 American Rheumatic Association, Sixth Western Regional Meeting and Conference November 18-19, 1977 7 National Institutes of Health, Site Visit December 2, 1977 8 Clinical Research Center, Site Visit December 14-15, 1977 9 National Institute of Arthritis, Metabolism, and Digestive Diseases, Annual Meeting January 11-14, 1978 10 University Hospital, Cancer Site Visit January 18, 1978 11 Kroc Foundation, Genetic Disease Collaborative Program January 18-20, 1978 12 Western Association of Physicians, Clinical Research Meeting February 1-3, 1978 13 Genetic Research Seminar February 5-6, 1978 14 Scripps Clinic and Research Foundation Conference February 9, 1978 15 Scientific Advisory Board Meeting February 15-16, 1978 16 Internal Medicine Topics Symposium February 20-24, 1978 17 Interpretative Enzymology III Course February 20-24, 1978 18-20 Vilcabama, Ecuador Meeting February 27-28, 1978 21 American College of Physicians, Postgraduate Genetics Course March 6-8, 1978 152 Conferences, Seminars, and Lectures 1978 1 Grand Rounds at the Veterans' Administration Hospital March 22, 1978 2 National Academy of Medicine, Symposium March 29, 1978 3 American College of Physicians, Annual Meeting April 17-20, 1978 4 Human Biochemical Genetics Program, Semi-Annual Information Exchange April 20, 1978 5 National Academy of Sciences, Annual Meeting April 24-26, 1978 6 Association of American Physicians, American Federation for Clinical Research, and American Society of Clinical Investigation Combined Meetings April 28-May 1, 1978 7 "Newer Concepts of Regulation of Human Purine Synthesis," University of California, Los Angeles, Lecture May 11, 1978 8 United States Naval Hospital Lecture May 25, 1978 9-10 Biochemistry/Immunology Meeting June 4-9, 1978 11-12 Secundum Prague Symposium on Rheumatology June 11-14, 1978 13-15 "Abnormalities of Purine Metabolism in Human Immunodeficiency Diseases," Summer Interpretive Program June 11-16, 1978 16 National Institutes of Health, Site Visit of Stanford August 13-15, 1978 153 Conferences, Seminars, and Lectures 1978-1979 1 Academy of Sciences of the USSR Series August 21-30, 1978 2 National Institute of Arthritis, Metabolism, and Digestive Diseases, Task Force September 15, 1978 3 American Society of Human Genetics Symposium October 4-7, 1978 4 Human Biochemical Genetics Program, Semi-Annual Information Exchange and Symposium October 12, 1978 5 Symposium on Models for Study of Inborn Errors October 18-21, 1978 6 Biological Basis for Immunodeficiency Symposium October 23-26, 1978 7 National Academy of the Sciences, Institute of Medicine, International Symposium on Biological Basis for Immunodeficiency October 26-27, 1978 8 School of Medicine Associates' (SOMA) Lecture Series November 1, 1978 9 American Rheumatic Association, 7th Western Regional Meeting November 16-18, 1978 10 Advisory Committee Meeting January 5-6, 1979 11 Analytical Biochemistry, Meeting with Executive Editors January 13, 1979 12 "Hereditary Disorders of Human Purine Metabolism," Louisiana State University Lecture January 24-26, 1979 13 National Academy of Sciences Meeting January 27, 1979 14 Pathophysiology Lecture for Second Year Medical Students February 1, 1979 15 American Federation for Clinical Research Seminar February 7-9, 1979 16 University Hospital Lecture March 9, 1979 17 Human Biochemical Genetics Program Semi-annual Information Exchange and Symposium March 15, 1979 18 Society for the Inherited Metabolic Disorders, Meeting March 25-28, 1979 19 Grand Rounds at Baylor College of Medicine March 29, 1979 154 Conferences, Seminars, and Lectures 1979 1 Federation of American Societies for Experimental Biology, 63rd Annual Meeting April 1-10, 1979 2 "Inherited Immunodeficiencies," Lecture April 12, 1979 3 National Academy of Sciences, Annual Meeting April 22-25, 1979 4 Brandeis University Lecture April 25, 1979 5 Association of American Physicians, Annual Conference May 5-7, 1979 6 Task Force Advisory Committee Meeting May 10-13, 1979 7 Thirty-ninth International Symposium on Purine Metabolism in Man June 11-15, 1979 8 Scripps Research Foundation Seminar July 19, 1979 9 Aging Seminar, Lecture Series September 25, 1979 10 American Society of Human Genetics, Annual Meeting October 3-6, 1979 11 Task Force Advisory Committee Meeting October 4-7, 1979 12 Human Biochemical Genetics Program, Semi-annual Information Exchange and Symposium October 11, 1979 13 National Academy of Sciences, Nominating Committee Meeting October 12, 1979 14-17 Conference on the Decline in Coronary Heart Disease Mortality October 24-25, 1979 18 Grand Rounds at the Veterans' Administration Hospital October 31, 1979 19 Cerebral Palsy Meeting November 3, 1979 20 The Biochemistry and Physiology of Glutamate, Proline, and Glutamine Interrelationships in Mammals Workshop November 4-7, 1979 21 Division of Rheumatology Site Visit November 9, 1979 22 "Update on Dermatology and Rheumatology for the Practicing Physician," Scripps Clinic and Research Foundation Conference November 5-9, 1979 23 The Herberden Society Annual Meeting and Seminar November 22-23, 1979 155 Conferences, Seminars, and Lectures 1980 1 Analytical Biochemistry Editorial Committee Meeting January 12, 1980 2 Clinical Correlation Chemistry Lecture January 23, 1980 3 National Academy of Sciences Membership Committee January 26, 1980 4 American Federation Clinical Research Conference February 6-8, 1980 5 Rheumatology Subspecialty, Fifth Annual Postgraduate Course March 6-7, 1980 6 The Society of Inherited Metabolic Disorders in Man, Third Annual Meeting March 9-11, 1980 7 Human Biochemical Genetics Program, Semi-Annual Information Exchange and Symposium March 20, 1980 8 "Inherited Immunodeficiencies," Inborn Errors of Metabolism Conference April 3, 1980 9 Federation of American Societies for Experimental Biology, General Meetings April 13-18, 1980 10 National Academy of Sciences, Annual Meeting April 21-23, 1980 11 Clinical Research Center, Public Lecture April 30, 1980 12 American Federation of Clinical Research, Conference May 10-12, 1980 13 "Medical Therapeutics," Lecture for Patholophysiology Course May 23, 1980 14 American Society of Biological Chemists Conference June 1-5, 1980 15 Muscular Dystrophy Association (MDA), Sixth International Scientific Conference June 1-6, 1980 16 National Institute of Arthritis, Metabolism, and Digestive Diseases Workshop on Intact Human Cell Lines June 12-13, 1980 156 Conferences, Seminars, and Lectures 1980 1 National Institutes of Health, Biological Mechanisms in Aging Conference June 23-25, 1980 2 Primary Immunodeficiencies Workshop July 17-20, 1980 3 Gordon Research Conference August 4-8, 1980 4-7 International Symposium on Inborn Errors of Metabolism September 2-5, 1980 8 Nineteenth International Symposium on the Regulation of Enzyme Activity October 6-7, 1980 9-11 Meeting on Nucleotides in Cancer Treatment October 12-15, 1980 12 Human Biochemical Genetics Program, Semi-Annual Information Exchange and Symposium October 23, 1980 13 Core Panel Meeting, National Research Plan on Aging November 13-14, 1980 14 The Permanente Medical Group Meeting December 12, 1980 157 Conferences, Seminars, and Lectures 1981 1 Task Force on Aging January 3-4, 1981 2 Gordon Research Conference January 12-16, 1981 3 Southern Society for Federal Research Meeting January 16, 1981 4 Department of Biological chemistry Lecture at the University of California, Irvine January 21, 1981 5 National Aging Research Panel, Task Force Meeting January 22, 1981 6 "Human Defects in Purine Metabolism," University of California, Santa Barbara, Lecture January 29, 1981 7 Analytical Biochemistry, Executive Editors Meeting January 31, 1981 8 American Federation for Clinical Research, Meeting on Aging February 4-6, 1981 9 Geriatrics in Internal Medicine Lecture February 15, 1981 10-12 Arthritis Foundation and American Rheumatism Association Conference February 19-20, 1981 13 Human Biochemical Genetics Program, Semi-Annual Information Exchange and Symposium March 17, 1981 14 Rheumatology Faculty Meeting March 26-29, 1981 15 Inherited Metabolic Disorders in Man Meeting April 5-8, 1981 16 Veterans' Administration Hospital, Arthritis Conference April 9, 1981 17 Institute for Continued Learning Lecture April 24, 1981 18-20 National Academy of Sciences, Annual Meeting April 27-29, 1981 21 Inherited Immunodeficiencies Lecture May 7, 1981 22 Pathophysiology Lecture on Gout May 8, 1981 23-24 International Symposium on Alkaptonuria May 27-28, 1981 158 Conferences, Seminars, and Lectures 1981 1-4 Basel Institute of Immunology Lecture June 11-16, 1981 5-8 International Congress of Rhumatology Conference June 21-27, 1981 9 Perspectives in Human Genetics, Summer Lecture Series July 15, 1981 10 Aging Panel Meeting July 23, 1981 11 Wyeth Symposium of Mexico City August 21, 1981 12 National Institutes of Health, Panel Meeting September 1, 1981 13 "New Developments in Gout and Uric Acid," Grand Rounds Lecture at University Hospital September 9, 1981 14 California Council on Gerontology and Geriatrics Meeting October 16, 1981 15 Symposium on Genetic Approaches to the Study of Metabolic Processes October 16-17, 1981 159 Conferences, Seminars, and Lectures 1981-1982 1 Human Biochemical Genetics Program, Semi-annual Information Exchange and Symposium October 19, 1981 2 Biochemistry Seminar October 22, 1981 3 National Institutes of Health, Panel on Aging November 13, 1981 5 Gerontological Society of America (GSA), Thirty-fourth Annual Meeting November 8-12, 1981 6 Fred Hutchinson Cancer Research Center Meeting January 11, 1982 7 The University of the Third Age Conference January 12, 1982 8 University of California, Irvine Biological Chemistry Correlate Program January 20, 1982 9 Analytical Biochemistry, Executive Editorial Committee Meeting January 30, 1982 10-11 "Gene Therapy," Cold Springs Harbor Symposium February 5-7, 1982 12 Western Gerontological Society, Twenty-eighth Annual Meeting February 27-March 3, 1982 13 The Society for Inherited Metabolic Disorders, Annual Meeting March 21-24, 1982 14 Human Biochemical Genetics Program, Semi-Annual Information Exchange and Symposium March 30, 1982 15 Federation of American Societies for Experimental Biology, Annual Meeting April 15-23, 1982 16 "Gout, " Pathophysiology Course April 23, 1982 17 National Academy of Sciences, Annual Meeting April 25-28, 1982 18 Population Association of America, 51st Annual Meeting April 29, 1982 19 Inborn Errors of Metabolism Lecture May 13, 1982 20 "The Role of Phosphates in Metabolic Control," Fiber Symposium May 24, 1982 21 "Inherited Disorders of Metabolism," ERM Course Lecture May 28, 1982 22 Charter Class Tenth Anniversary June 5, 1982 23-24 International Symposium on Adenosine June 7-11, 1982 160 Conferences, Seminars, and Lectures 1982 1 Fourth International Symposium on Human Purine and Pyrimidine Metabolism June 13-18, 1982 2-3 "Functional Disability in the Hospitalized Elderly," Arthritis and Rheumatology Council Lecture June 23, 1982 4 Human Biochemical Genetics Program, Semi-annual Information Exchange and Symposium September 17, 1982 161 Conferences, Seminars, and Lectures 1983 1-2 Gordon Research Conference February 6-11, 1983 3 American Federation for Clinical Research, Annual Meeting February 9-11, 1983 4 University of South Carolina (USC), Aging Meeting February 14, 1983 5-7 Analytical Biochemistry, Executive Editors, Annual Meeting February 18, 1983 8-12 National Academy of Sciences, Annual Meeting April 24-27, 1983 13 Association of American Physicians, Annual Meeting April 29-May 3, 1983 14 Western Behavioral Sciences Institute Conference May 3, 1983 15 Conference on Genetic Consequences of Nucleotide Pool Imbalances May 9-11, 1983 16 "Frontiers in Longevity Research," University of California, Los Angeles, Extension Course September 23-24, 1983 17 Frontiers in Alzheimer's Disease Symposium September 24, 1983 18 American Aging Association Conference October 6-8, 1983 162 Conferences, Seminars, and Lectures 1984 1 Interdisciplinary Course on Aging January 24, 1984 2-4 A Clinical Symposium on Gerontology and Healthful Aging February 2-4, 1984 5 Western Section of the American Federation for Clinical Research, Annual Meeting February 7-10, 1984 6-7 Analytical Biochemistry, Executive Editors, Annual Meeting February 11, 1984 8 Institute for Continued Learning Lecture February 17, 1984 9 Oxygen Radicals Workshop February 24, 1984 10 San Diego Country Pharmacists Association Lecture February 27, 1984 11 Human Biochemical Genetics Program, Semi-annual Information Exchange and Symposium March 20, 1984 12 The Society for Inherited Metabolic Disorders Conference March 25-28, 1984 13 University Hospital, Talk to Arthritic Patients March 30, 1984 14 San Diego Grantmakers Panel on Aging April 13, 1984 15 Dixie Junior College, D-Week Program April 13-14, 1984 16 Biology Lecture at University of California, San Diego April 24, 1984 17 National Institutes of Health, Department of Health and Human Services, Advisory Panel Workshop April 27, 1984 163 Conferences, Seminars, and Lectures 1987 1 Mount Ararat Senior Group Lecture January 8, 1987 2 "The Aging Brain," and "Theories on Aging and Human Syndromes of Accelerated Aging," University of California, San Diego Mini-Series Lecture January 13, 1987 3 Nucleic Acid Research Institute, Scientific Advancement Committee Meeting January 15, 1987 4 Senior Health Care Lecture January 30, 1987 5 Oxygen Radicals and Antioxidants in Cancer and Aging Workshop February 3-6, 1987 6 Carmel Medical Meeting February 16-19, 1987 7 Analytical Biochemistry, Executive Meeting February 21, 1987 8 Medical Auxiliary, Health Lecture Day March 3, 1987 9 American Association of University Women March 21, 1987 10 National Institutes of Health, Board of Scientific Counselors Meeting April 20-22, 1987 11 National Academy of Sciences Annual Meeting April 26-29, 1987 12 "Myths and Realities of Aging," LaJolla Centennial Celebration Lecture May 3, 1987 13 Late Adulthood Course, Lecture at University of California, San Diego May 13, 1987 14-15 Fourth International Congress on Oxygen Radicals June 27-July 3, 1987 16 Older Adult Symposium August 28, 1987 17 Nucleic Acid Research Institute, Scientific Advancement Committee September 14, 1987 18 "Myths and Realities of Aging," Western School of Law Lecture September 16, 1987 19-23 Rheumatology Lecture at Yokohama City University October 24-25, 1987 164 Conferences, Seminars, and Lectures 1987-1988 1 Review of Research Grants on Alzheimer's Disease by the Commonwealth Fund November 2, 1987 2 "Aging into the Twenty-first Century," Lecture November 17, 1987 3 Third Metabolism, Biochemical and Physiological Accompaniment of Aging Conference November 18, 1987 4 Continuing Education at the Geriatric Medical Conference February 15-17, 1988