The A. Isabella Downs Scrapbook was assembled by Downs to document her student years at Oregon Agricultural College (OAC) from 1913 to 1916. It includes clippings, dance cards, programs, ticket stubs, notes, various ephemera, and numerous photographs. The materials document student activities and the campus environment during the mid-1910s as well as other pharmacy students and the Class of 1916. Of special note is a student season athletic ticket booklet for 1915-1916 which includes ticket coupons for football, baseball, track, and other campus athletic events. The only item dated earlier than 1913 is Downs' 1910 report card for her 10th grade year at the Stayton, Oregon, school.

Most of the photographs are snapshots of other Oregon Agricultural College students. The scrapbook includes many images of women students; student outings to the Oregon coast, including Seaside; and campus events such as football games, commencement, May Day pageants, the annual tug-of-war, and homecoming. Photographs of snow on campus and students skating and playing ice hockey on a frozen lake are included. An image of flooding, probably near Corvallis, is also part of the scrapbook. Snapshots of picnics, camping trips, and an automobile driving through a dry landscape (perhaps Eastern Oregon?) are included; several images of women in the woods with a rifle (hunting?) are of special note. The scrapbook includes images of campus buildings as well as several structures in downtown Corvallis and the Presbyterian Church in Corvallis. Images of "Dad" and "Mother" Hunter, the cooks at Cauthorn Hall, are included, as well as several snapshots of women students on the Cauthorn Hall fire escape.

The scrapbook includes several non-OAC images of interest, one of which is a a group photograph of Junction City, Oregon, High School students. Several photographs of Native American children, adults, tepees, and a parade are part of the scrapbook; these images may have been taken in Wyoming.