The long and complex, if outwardly simple, life of Wilhelm Suksdorf began in rural Germany, near Kiel, in 1850. At the age of eight he emigrated to northeastern Iowa with his family. He lived there until 1874. In 1876 he was enrolled in a science/agriculture course at the University of California. Before graduating, however, he left school to join his father and several brothers at White Salmon, Washington, where he entered into their various farming and town promotion activities.

He started making botanical observations of an informal sort in Iowa, continued in California and began serious reconnaissance and collecting of Washington plants during the summer vacation of 1875. As much of the Washington vegetation could not be identified with existing manuals, in 1878 Suksdorf began corresponding with Asa Gray at Harvard University, in an effort to have his collection identified and named. Encouraged by Gray, who named a genus of plants for him, and by a visiting expedition of botanists in 1880, Suksdorf decided to make a serious distribution of Washington plants. These he offered for sale in 1882, the first of his thirteen fascicles of Washington plants.

In 1886, Gray asked Suksdorf to join him at Harvard as an assistant, apparently intending that the position would become permanent. A combination of complex circumstances, along with various physical and mental health problems which plagued him throughout his life, led Suksdorf to abandon Harvard in 1888. After a time of inactivity, he returned to collecting Washington plants and to a regular pattern of publication of his findings. Difficulties arose, however, because of his limitations with English and a strong personal desire to write in German. Consequently, many of his articles appeared in German and Austrian journals, or in obscure American journals which would carry articles written in German. This position, along with his strong adherence to the "International Rule" school of thought, led him into many minor disputes with botanists for the rest of his life. In the 1920s, he resolved some of these difficulties by founding a personal journal, Werdenda, which gave him an outlet for his views.

Suksdorf continued to live at Bingen, Washington, a town he and his brothers founded, for the rest his life and his botanical labors accordingly tended to reflect the vegetation of adjacent Klickitat County. This area contained vegetation representative of both humid, wooded Western Washington and arid, open Eastern Washington along with a major alpine area, Mt. Adams, which Suksdorf, following Indian practice, called Mt. Paddo. Thus he was exposed to much of the state’s varied flora without traveling great distances. He did, nevertheless, collect plants in the Spokane area in parts of Oregon and Idaho near to Washington, at one location in Montana and while on a major trip to California in 1913. In the 1920s he spent two winters at Washington State University, as a special fellow of the herbarium.

Suksdorf’s outlook on botany had been colored by his early exposure to the ideas of Asa Gray and the basic ideas of the Candollean school, as well as by his own personal experiences and emotions relative to the out-of-doors and to plants. Occupationally, philosophically, scientifically and emotionally he was a "naturalist," reflecting every sense of the meaning of the term. This led him to some practices which caused many to regard him as an eccentric: his reclusiveness, his preferences for field botany over laboratory study, and his tendency to be a splitter of species. For decades he fought against those botanical ideas which came from abstract study in herbaria and libraries and insisted that plants must be seen in the field for an understanding. Although this fight with academic botanists was generally a losing battle, Suksdorf continued to hope for a return of naturalism even to the later years of his life. He expressed this idea in 1928 when he wrote, "A collector sees the plants in the field and mostly many of each kind he collects, but his notes or remarks are seldom considered of importance. That was so, at least in the past. But I knew one botanist who was different; that was Dr. Gray. To him the collector was a helper, not merely a collector." (16 June 1928, Harold St. John Papers).