Cindy Domingo, along with her brothers and sisters, played a key role in the Asian American and Filipino youth movements of the 1970s, and has been a community leader in the Seattle area since then. In the 1970s, she helped lead solidarity campaigns on the University of Washington campus against the Marcos dictatorship in the Philippines. She was active in the Union of Democratic Filipinos (KDP), for which she did organizing in Seattle and Oakland. On June 1st, 1981, Cindy's brother Silme Domingo, a KDP organizer and union reform activist in ILWU Local 37, was assassinated along with fellow union leader Gene Viernes. For the next ten years, Cindy served as the National Chair for the Committee for Justice for Domingo and Viernes. The campaign resulted in the conviction of the former ILWU Local 37 President and family friend Tony Baruso for organizing the assassination, and also proved that the murders had been ordered by the Marcos regime with U.S. government knowledge.

Cindy Domingo was an active member of the Washington State Rainbow Coalition in the 1980s, and served on the boards of the Church Council of Greater Seattle, LELO, and the International Examiner. She has been Board President of the Center for Social Justice and co-chair of U.S. Women & Cuba Collaboration, and currently serves as the Legislative Aide to King County Councilmember Larry Gossett.